Cited 17 times in
Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 이필휴 | - |
dc.date.accessioned | 2018-08-28T16:44:08Z | - |
dc.date.available | 2018-08-28T16:44:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0022-3050 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161886 | - |
dc.description.abstract | BACKGROUND: Neuropsychiatric symptoms impact the patients' quality of life and caregivers' burdens in Parkinson's disease (PD). We aimed to investigate the effects of striatal dopaminergic depletion and brain atrophy on the neuropsychiatric symptoms of patients with PD. METHODS: Two hundred and seven patients with de novo drug-naive PD underwent dopamine transporter (DAT) positron emission tomography and brain MRI scanning. In addition, the patients were assessed with caregiver-administered neuropsychiatric inventory (NPI) questionnaires. To evaluate the effects of DAT uptake, subcortical volume and cortical thinning on the patients' neuropsychiatric symptoms, we performed logistic regression and negative binomial regression analyses on the NPI data after controlling for possible confounders. RESULTS: Frontal cortical thinning was associated with the presence of nighttime behaviour and irritability, and the thinning correlated with the severity of the nighttime behaviour. Temporal cortical thinning was associated with the presence of aggression/agitation, and it correlated with the severity of the aggression/agitation. Subcortical atrophy in the accumbens was associated with the presence of disinhibition and correlated with the severity of the disinhibition. Putamen atrophy and insular thinning were independently associated with the presence of apathy, but only insular thinning correlated with the severity of the apathy. Of the predictors, only frontal cortical thinning correlated with the total NPI score. CONCLUSIONS: The results of this study suggested that accumbens atrophy and frontotemporal cortical thinning, especially frontal cortical thinning, independently contributed to neuropsychiatric symptoms in patients with PD, while DAT uptake did not affect the neuropsychiatric symptoms. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isPartOf | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.contributor.googleauthor | Seun Jeon | - |
dc.contributor.googleauthor | Sohoon Yoon | - |
dc.contributor.googleauthor | Seong Woo Kang | - |
dc.contributor.googleauthor | KyoungWon Baik | - |
dc.contributor.googleauthor | Yoonju Lee | - |
dc.contributor.googleauthor | Su Jin Chung | - |
dc.contributor.googleauthor | Jungsu S Oh | - |
dc.contributor.googleauthor | Hyojeong Moon | - |
dc.contributor.googleauthor | Jae Seung Kim | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young Ho Sohn | - |
dc.identifier.doi | 10.1136/jnnp-2017-316075 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A03270 | - |
dc.relation.journalcode | J01628 | - |
dc.identifier.eissn | 1468-330X | - |
dc.identifier.pmid | 28951497 | - |
dc.identifier.url | https://jnnp.bmj.com/content/89/2/197 | - |
dc.subject.keyword | cortical thickness | - |
dc.subject.keyword | dopamine transporter imaging | - |
dc.subject.keyword | neuropsychiatric symptom | - |
dc.subject.keyword | parkinson's disease | - |
dc.subject.keyword | subcortical atrophy | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Ye, Byoung Seok | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | Ye, Byoung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.citation.volume | 89 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.89(2) : 197-204, 2018 | - |
dc.identifier.rimsid | 59477 | - |
dc.type.rims | ART | - |
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