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The Within-Group Discrimination Ability of the Cancer of the Prostate Risk Assessment Score for Men with Intermediate-Risk Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | 이주용 | - |
dc.contributor.author | 정해도 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 함원식 | - |
dc.date.accessioned | 2018-08-28T16:44:02Z | - |
dc.date.available | 2018-08-28T16:44:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161884 | - |
dc.description.abstract | BACKGROUND: Significant clinical heterogeneity within contemporary risk group is well known, particularly for those with intermediate-risk prostate cancer (IRPCa). Our study aimed to analyze the ability of the Cancer of the Prostate Risk Assessment (CAPRA) score to discern between favorable and non-favorable risk in patients with IRPCa. METHODS: We retrospectively reviewed the data of 203 IRPCa patients who underwent extraperitoneal robot-assisted radical prostatectomy (RARP) performed by a single surgeon. Pathologic favorable IRPCa was defined as a Gleason score </= 6 and organ-confined stage at surgical pathology. The CAPRA score was compared with two established criteria for the within-group discrimination ability. RESULTS: Overall, 38 patients (18.7% of the IRPCa cohort) had favorable pathologic features after RARP. The CAPRA score significantly correlated with established criteria I and II and was inversely associated with favorable pathology (all P < 0.001). The area under the receiver operating characteristic curve for the discriminative ability between favorable and non-favorable pathology was 0.679 for the CAPRA score and 0.610 and 0.661 for established criteria I and II, respectively. During a median 37.8 (interquartile range, 24.6-60.2) months of follow-up, 66 patients (32.5%) experienced biochemical recurrence (BCR). Cox regression analysis revealed that the CAPRA score, as a continuous sum score model or 3-group risk model, was an independent predictor of BCR after RARP. CONCLUSION: The within-group discrimination ability of preoperative CAPRA score might help in patient counseling and selecting optimal treatments for those with IRPCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The Within-Group Discrimination Ability of the Cancer of the Prostate Risk Assessment Score for Men with Intermediate-Risk Prostate Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Ho Won Kang | - |
dc.contributor.googleauthor | Hae Do Jung | - |
dc.contributor.googleauthor | Joo Yong Lee | - |
dc.contributor.googleauthor | Jong Kyou Kwon | - |
dc.contributor.googleauthor | Seong Uk Jeh | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e36 | - |
dc.contributor.localId | A03161 | - |
dc.contributor.localId | A03759 | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 29349945 | - |
dc.subject.keyword | Biochemical Recurrence | - |
dc.subject.keyword | Prostate-specific Antigen | - |
dc.subject.keyword | Prostate-specific Antigen Density | - |
dc.subject.keyword | Prostatectomy | - |
dc.subject.keyword | Prostatic Neoplasms | - |
dc.contributor.alternativeName | Lee, Joo Yong | - |
dc.contributor.alternativeName | Jung, Hae Do | - |
dc.contributor.alternativeName | Cho, Kang Su | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Ham, Won Sik | - |
dc.contributor.affiliatedAuthor | Lee, Joo Yong | - |
dc.contributor.affiliatedAuthor | Jung, Hae Do | - |
dc.contributor.affiliatedAuthor | Cho, Kang Su | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Ham, Won Sik | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e36 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.33(5) : e36, 2018 | - |
dc.identifier.rimsid | 59475 | - |
dc.type.rims | ART | - |
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