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The Within-Group Discrimination Ability of the Cancer of the Prostate Risk Assessment Score for Men with Intermediate-Risk Prostate Cancer

DC FieldValueLanguage
dc.contributor.author이주용-
dc.contributor.author정해도-
dc.contributor.author조강수-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.date.accessioned2018-08-28T16:44:02Z-
dc.date.available2018-08-28T16:44:02Z-
dc.date.issued2018-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161884-
dc.description.abstractBACKGROUND: Significant clinical heterogeneity within contemporary risk group is well known, particularly for those with intermediate-risk prostate cancer (IRPCa). Our study aimed to analyze the ability of the Cancer of the Prostate Risk Assessment (CAPRA) score to discern between favorable and non-favorable risk in patients with IRPCa. METHODS: We retrospectively reviewed the data of 203 IRPCa patients who underwent extraperitoneal robot-assisted radical prostatectomy (RARP) performed by a single surgeon. Pathologic favorable IRPCa was defined as a Gleason score </= 6 and organ-confined stage at surgical pathology. The CAPRA score was compared with two established criteria for the within-group discrimination ability. RESULTS: Overall, 38 patients (18.7% of the IRPCa cohort) had favorable pathologic features after RARP. The CAPRA score significantly correlated with established criteria I and II and was inversely associated with favorable pathology (all P < 0.001). The area under the receiver operating characteristic curve for the discriminative ability between favorable and non-favorable pathology was 0.679 for the CAPRA score and 0.610 and 0.661 for established criteria I and II, respectively. During a median 37.8 (interquartile range, 24.6-60.2) months of follow-up, 66 patients (32.5%) experienced biochemical recurrence (BCR). Cox regression analysis revealed that the CAPRA score, as a continuous sum score model or 3-group risk model, was an independent predictor of BCR after RARP. CONCLUSION: The within-group discrimination ability of preoperative CAPRA score might help in patient counseling and selecting optimal treatments for those with IRPCa.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJournal of Korean Medical Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Within-Group Discrimination Ability of the Cancer of the Prostate Risk Assessment Score for Men with Intermediate-Risk Prostate Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorHo Won Kang-
dc.contributor.googleauthorHae Do Jung-
dc.contributor.googleauthorJoo Yong Lee-
dc.contributor.googleauthorJong Kyou Kwon-
dc.contributor.googleauthorSeong Uk Jeh-
dc.contributor.googleauthorKang Su Cho-
dc.contributor.googleauthorWon Sik Ham-
dc.contributor.googleauthorYoung Deuk Choi-
dc.identifier.doi10.3346/jkms.2018.33.e36-
dc.contributor.localIdA03161-
dc.contributor.localIdA03759-
dc.contributor.localIdA03801-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid29349945-
dc.subject.keywordBiochemical Recurrence-
dc.subject.keywordProstate-specific Antigen-
dc.subject.keywordProstate-specific Antigen Density-
dc.subject.keywordProstatectomy-
dc.subject.keywordProstatic Neoplasms-
dc.contributor.alternativeNameLee, Joo Yong-
dc.contributor.alternativeNameJung, Hae Do-
dc.contributor.alternativeNameCho, Kang Su-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHam, Won Sik-
dc.contributor.affiliatedAuthorLee, Joo Yong-
dc.contributor.affiliatedAuthorJung, Hae Do-
dc.contributor.affiliatedAuthorCho, Kang Su-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHam, Won Sik-
dc.citation.volume33-
dc.citation.number5-
dc.citation.startPagee36-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, Vol.33(5) : e36, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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