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Cited 11 times in

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

DC FieldValueLanguage
dc.contributor.author김남희-
dc.contributor.author김현실-
dc.contributor.author육종인-
dc.contributor.author차용훈-
dc.contributor.author조은애-
dc.date.accessioned2018-08-28T16:41:59Z-
dc.date.available2018-08-28T16:41:59Z-
dc.date.issued2018-
dc.identifier.issn1976-9148-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161848-
dc.description.abstractDuring cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells under metabolic stress conditions, such as metabolic resource limitation and therapeutic intervention. NADPH is essential for scavenging of reactive oxygen species (ROS) mainly derived from oxidative phosphorylation required for ATP generation. Thus, metabolic reprogramming of NADPH homeostasis is an important step in cancer progression as well as in combinational therapeutic approaches. In mammalian, the pentose phosphate pathway (PPP) and one-carbon metabolism are major sources of NADPH production. In this review, we focus on the importance of glucose flux control towards PPP regulated by oncogenic pathways and the potential therein for metabolic targeting as a cancer therapy. We also summarize the role of Snail (Snai1), an important regulator of the epithelial mesenchymal transition (EMT), in controlling glucose flux towards PPP and thus potentiating cancer cell survival under oxidative and metabolic stress.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Applied Pharmacology-
dc.relation.isPartOfBiomolecules & Therapeutics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Pentose Phosphate Pathway as a Potential Target for Cancer Therapy-
dc.typeArticle-
dc.contributor.collegeResearch Institutes-
dc.contributor.departmentOral Cancer Research Institute-
dc.contributor.googleauthorEunae Sandra Cho-
dc.contributor.googleauthorYong Hoon Cha-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorJong In Yook-
dc.identifier.doi10.4062/biomolther.2017.179-
dc.contributor.localIdA00360-
dc.contributor.localIdA01121-
dc.contributor.localIdA02536-
dc.contributor.localIdA04000-
dc.relation.journalcodeJ00324-
dc.identifier.eissn2005-4483-
dc.identifier.pmid29212304-
dc.subject.keywordEpithelial-mesenchymal transition-
dc.subject.keywordGlucose-6-phosphate dehydrogenase-
dc.subject.keywordNADPH-
dc.subject.keywordPentose phosphate pathway-
dc.subject.keywordSnail-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameCha, Yong Hoon-
dc.contributor.affiliatedAuthorKim, Nam Hee-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorCha, Yong Hoon-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage29-
dc.citation.endPage38-
dc.identifier.bibliographicCitationBiomolecules & Therapeutics, Vol.26(1) : 29-38, 2018-
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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