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The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

Authors
 Eunae Sandra Cho  ;  Yong Hoon Cha  ;  Hyun Sil Kim  ;  Nam Hee Kim  ;  Jong In Yook 
Citation
 Biomolecules & Therapeutics, Vol.26(1) : 29-38, 2018 
Journal Title
 Biomolecules & Therapeutics 
ISSN
 1976-9148 
Issue Date
2018
Keywords
Epithelial-mesenchymal transition ; Glucose-6-phosphate dehydrogenase ; NADPH ; Pentose phosphate pathway ; Snail
Abstract
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells under metabolic stress conditions, such as metabolic resource limitation and therapeutic intervention. NADPH is essential for scavenging of reactive oxygen species (ROS) mainly derived from oxidative phosphorylation required for ATP generation. Thus, metabolic reprogramming of NADPH homeostasis is an important step in cancer progression as well as in combinational therapeutic approaches. In mammalian, the pentose phosphate pathway (PPP) and one-carbon metabolism are major sources of NADPH production. In this review, we focus on the importance of glucose flux control towards PPP regulated by oncogenic pathways and the potential therein for metabolic targeting as a cancer therapy. We also summarize the role of Snail (Snai1), an important regulator of the epithelial mesenchymal transition (EMT), in controlling glucose flux towards PPP and thus potentiating cancer cell survival under oxidative and metabolic stress.
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DOI
10.4062/biomolther.2017.179
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cho, Eunae(조은애산드라) ORCID logo https://orcid.org/0000-0002-0820-3019
Cha, Yong Hoon(차용훈) ORCID logo https://orcid.org/0000-0003-1761-3260
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161848
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