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Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 나준채 | - |
dc.contributor.author | 윤영은 | - |
dc.contributor.author | 이형호 | - |
dc.contributor.author | 한웅규 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2018-07-20T12:04:55Z | - |
dc.date.available | 2018-07-20T12:04:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161740 | - |
dc.description.abstract | To determine the suitability of serum endocan (ESM-1) levels for diagnosing and monitoring renal cell carcinoma (RCC), we measure serum ESM-1 levels in 56 RCC patients who had undergone radical or partial nephrectomies and 56 age- and sex-matched healthy kidney donors. Measurements were made before and 1 month and 3 months after surgery. The areas under the curve (AUCs) were determined from receiver operating characteristic (ROC) analyses. RCC patients had higher mean serum ESM-1 levels than control subjects (0.59 ± 0.07 vs. 0.52 ± 0.08 ng/mL, P < 0.001), with an AUC of 0.721 (95% CI: 0.628-0.817). In patients with tumors larger than 2 cm (n = 40) and those with clear-cell histology (n = 44), the AUCs for ESM-1 were 0.771 and 0.721, respectively. In control subjects, serum ESM-1 levels were higher in older (>50 years) individuals (P < 0.001). Among the study cohort, the AUCs for ESM-1 were 0.813 in individuals 50 years of age or younger (n = 55) and 0.637 in individuals older than 50 years (n = 57). In RCC patients, serum ESM-1 levels were reduced 1 month (P = 0.047) and 3 months (P = 0.009) after surgery. These results suggest serum ESM-1 can serve as a serologic biomarker for diagnosing and monitoring RCC, particularly in patients younger than 50 years. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Kwang Hyun Kim | - |
dc.contributor.googleauthor | Hyung Ho Lee | - |
dc.contributor.googleauthor | Young Eun Yoon | - |
dc.contributor.googleauthor | Joon Chae Na | - |
dc.contributor.googleauthor | Sook Young Kim | - |
dc.contributor.googleauthor | Young In Cho | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.identifier.doi | 10.18632/oncotarget.23087 | - |
dc.contributor.localId | A04742 | - |
dc.contributor.localId | A02581 | - |
dc.contributor.localId | A04647 | - |
dc.contributor.localId | A04308 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 29416643 | - |
dc.subject.keyword | area under curve | - |
dc.subject.keyword | carcinoma | - |
dc.subject.keyword | early diagnosis | - |
dc.subject.keyword | renal cell | - |
dc.contributor.alternativeName | Na, Joon Chae | - |
dc.contributor.alternativeName | Yoon, Young Eun | - |
dc.contributor.alternativeName | Lee, Hyung Ho | - |
dc.contributor.alternativeName | Han, Woong Kyu | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Na, Joon Chae | - |
dc.contributor.affiliatedAuthor | Yoon, Young Eun | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Ho | - |
dc.contributor.affiliatedAuthor | Han, Woong Kyu | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | 나준채 | - |
dc.contributor.affiliatedAuthor | 윤영은 | - |
dc.contributor.affiliatedAuthor | 이형호 | - |
dc.contributor.affiliatedAuthor | 한웅규 | - |
dc.contributor.affiliatedAuthor | 홍성준 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 662 | - |
dc.citation.endPage | 667 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.9(1) : 662-667, 2018 | - |
dc.identifier.rimsid | 59357 | - |
dc.type.rims | ART | - |
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