Cited 24 times in
Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승업 | - |
dc.contributor.author | 김용석 | - |
dc.contributor.author | 이정일 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2018-07-20T12:04:44Z | - |
dc.date.available | 2018-07-20T12:04:44Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161735 | - |
dc.description.abstract | Recently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis (n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P < 0.05). The mREACH-B significantly predicted HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P < 0.001) and it performed similarly or significantly better than the PAGE-B and LSM-HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Yeon Seok Seo | - |
dc.contributor.googleauthor | Byoung Kuk Jang | - |
dc.contributor.googleauthor | Soon Ho Um | - |
dc.contributor.googleauthor | Jae Seok Hwang | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Sang Gyune Kim | - |
dc.contributor.googleauthor | Kwan Sik Lee | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Young Seok Kim | - |
dc.contributor.googleauthor | Jung Il Lee | - |
dc.identifier.doi | 10.18632/oncotarget.22375 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A05315 | - |
dc.contributor.localId | A03122 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 29348900 | - |
dc.subject.keyword | hepatitis B | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | liver stiffness | - |
dc.subject.keyword | risk prediction | - |
dc.subject.keyword | transient elastography | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Kim, Young Seok | - |
dc.contributor.alternativeName | Lee, Jung Il | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Kim, Young Seok | - |
dc.contributor.affiliatedAuthor | Lee, Jung Il | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.citation.volume | 8 | - |
dc.citation.number | 68 | - |
dc.citation.startPage | 113213 | - |
dc.citation.endPage | 113224 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.8(68) : 113213-113224, 2017 | - |
dc.identifier.rimsid | 59352 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.