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Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study

DC FieldValueLanguage
dc.contributor.author김승업-
dc.contributor.author김용석-
dc.contributor.author이정일-
dc.contributor.author한광협-
dc.date.accessioned2018-07-20T12:04:44Z-
dc.date.available2018-07-20T12:04:44Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161735-
dc.description.abstractRecently, modified REACH-B (mREACH-B) risk prediction model for hepatocellular carcinoma (HCC) development was proposed. We validated the accuracy of the mREACH-B model and compared its accuracy with those of other prediction models. Between 2006 and 2012, 1,241 patients with chronic hepatitis B (CHB) were recruited. All patients underwent transient elastography at enrollment. The median age of the study population (840 males, 401 females) was 49 years. The median PAGE-B, LSM-HCC, and mREACH-B values were 10, 10, and 8, respectively. Among patients without cirrhosis (n = 940, 75.7%), the median REACH-B value was 9. During the follow-up period (median 77.4 months), 66 (5.3%) and 83 (6.7%) patients developed HCC and liver-related events (LRE), respectively. Higher liver stiffness (LS) independently predicted HCC (hazard ratio [HR] = 1.047) and LRE development (HR = 1.047) (all P < 0.05). The mREACH-B significantly predicted HCC (AUC = 0.824 at 3-year and 0.750 at 5-year) and LRE development (AUC = 0.782 at 3-year and 0.739 at 5-year) (all P < 0.001) and it performed similarly or significantly better than the PAGE-B and LSM-HCC (AUC = 0.715-0.809 at 3-year and 0.719-0.742 at 5-year for HCC; AUC = 0.704-0.777 at 3-year and 0.721-0.735 at 5-year for LRE). Among patients without cirrhosis, mREACH-B predicted HCC (AUC = 0.803 vs. 0.654-0.816 at 3-year and 0.684 vs. 0.639-0.738 at 5-year) and LRE development (AUC = 0.734 vs. 0.619-0.789 at 3-year and 0.674 vs. 0.626-0.729 at 5-year) similarly to PAGE-B, REACH-B, and LSM-HCC. mREACH-B appropriately predicted HCC and LRE development in patients with CHB and showed similar or superior accuracy to those of PAGE-B, REACH-B, and LSM-HCC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleValidation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYeon Seok Seo-
dc.contributor.googleauthorByoung Kuk Jang-
dc.contributor.googleauthorSoon Ho Um-
dc.contributor.googleauthorJae Seok Hwang-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorSang Gyune Kim-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorJung Il Lee-
dc.identifier.doi10.18632/oncotarget.22375-
dc.contributor.localIdA00654-
dc.contributor.localIdA05315-
dc.contributor.localIdA03122-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid29348900-
dc.subject.keywordhepatitis B-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordliver stiffness-
dc.subject.keywordrisk prediction-
dc.subject.keywordtransient elastography-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Young Seok-
dc.contributor.alternativeNameLee, Jung Il-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Young Seok-
dc.contributor.affiliatedAuthorLee, Jung Il-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume8-
dc.citation.number68-
dc.citation.startPage113213-
dc.citation.endPage113224-
dc.identifier.bibliographicCitationONCOTARGET , Vol.8(68) : 113213-113224, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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