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Prevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease

DC FieldValueLanguage
dc.contributor.author김광준-
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이혜원-
dc.contributor.author한광협-
dc.date.accessioned2018-07-20T12:04:12Z-
dc.date.available2018-07-20T12:04:12Z-
dc.date.issued2017-
dc.identifier.issn0163-2116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161727-
dc.description.abstractBACKGROUND/AIMS: Transient elastography (TE) can be used to assess the degree of liver fibrosis and steatosis. We investigated the prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) with or without significant liver fibrosis in the general population. METHODS: A total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. TE-defined NAFLD was defined as a controlled attenuation parameter of ≥250 dB/m, and significant liver fibrosis was defined as a liver stiffness (LS) value of ≥8 kPa. RESULTS: Overall, 1178 (42.9%) subjects had NAFLD. Subjects with NAFLD had significantly higher alanine aminotransferase (ALT) levels and a higher prevalence of parameters related to metabolic syndrome, such as high blood pressure, a high body mass index (BMI), glucose intolerance, and dyslipidemia than did subjects without NAFLD (all P < 0.05). Age, male gender, ALT level, serum albumin, BMI, diabetes, hypertriglyceridemia, and LS values independently showed positive associations with the presence of NAFLD (all P < 0.05). In addition, concomitant significant liver fibrosis was identified in 60 (5.1%) subjects with NAFLD, and its independent predictors were age [odds ratio (OR) 1.054], ALT level (OR 1.019), BMI (OR 1.217), and diabetes (OR 1.987) (all P < 0.05). CONCLUSIONS: We found that the prevalence of subjects with NAFLD was high (42.9%), and 5.1% of them had concomitant significant liver fibrosis. The risk factors found in this study can help identify which subjects with NAFLD are vulnerable to fibrosis progression.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Science + Business Media-
dc.relation.isPartOfDigestive Diseases and Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlanine Transaminase/blood-
dc.subject.MESHBody Mass Index-
dc.subject.MESHDyslipidemias/complications-
dc.subject.MESHElasticity Imaging Techniques/methods-
dc.subject.MESHFemale-
dc.subject.MESHGlucose Intolerance/complications-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/complications-
dc.subject.MESHLiver/diagnostic imaging-
dc.subject.MESHLiver Cirrhosis/diagnosis-
dc.subject.MESHLiver Cirrhosis/epidemiology*-
dc.subject.MESHLiver Cirrhosis/etiology*-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/complications-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/blood-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/complications*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/diagnostic imaging-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Factors-
dc.subject.MESHSerum Albumin/analysis-
dc.subject.MESHYoung Adult-
dc.titlePrevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorKwang-Hyub Han-
dc.identifier.doi10.1007/s10620-017-4592-0-
dc.contributor.localIdA00317-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03318-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ00737-
dc.identifier.eissn1573-2568-
dc.identifier.pmid28523578-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10620-017-4592-0-
dc.subject.keywordControlled attenuation parameter-
dc.subject.keywordFibrosis-
dc.subject.keywordNonalcoholic fatty liver disease-
dc.subject.keywordSteatosis-
dc.subject.keywordTransient elastography-
dc.contributor.alternativeNameKim, Kwang Joon-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Hye Won-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Hye Won-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume62-
dc.citation.number8-
dc.citation.startPage2150-
dc.citation.endPage2158-
dc.identifier.bibliographicCitationDigestive Diseases and Sciences, Vol.62(8) : 2150-2158, 2017-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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