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Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.date.accessioned2018-07-20T12:04:01Z-
dc.date.available2018-07-20T12:04:01Z-
dc.date.issued2017-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161724-
dc.description.abstractThis study investigated the effects of the presence of type 2 diabetes mellitus (T2D) and/or chronic liver disease (CLD) on the incidence and prognosis of dementia during a 10-year period in Korea using a nationwide population-based dataset from the Korea National Health Insurance Service.To assess the impact of T2D and CLD on the incidence of dementia, we included subjects aged ≥60 years without dementia, T2D, and CLD from 2003 to 2005. We created another cohort for evaluating the all-cause mortality in subjects with dementia between 2003 and 2005. The participants were categorized into 4 groups: control (neither CLD nor T2D), CLD-only, T2D-only, and T2D-and-CLD groups, and they were followed up until 2013.The incidence of dementia was higher in the T2D-only group than in the control and CLD-only groups (2.78 vs. 2.04 and 2.00 per 1000 person-years). After adjustment for age, gender, and comorbid conditions, both T2D and CLD increased the risk of any type of dementia; however, the impact of CLD alone was much lower [hazard ratio (HR) 1.07, 95% confidence interval (CI): 1.06-1.08] than that of T2D alone (HR 1.27, 95% CI: 1.27-1.28). The risk of dementia did not significantly change in patients with the co-occurrence of T2D and CLD compared to those with T2D alone. The all-cause mortality rate was the lowest in the control group (2.59 per 1000 person-years) and the highest in the T2D-and-CLD group (3.77 per 1000 person-years). Presence of T2D or CLD alone was associated with higher mortality (HR 1.46 and HR 1.21, respectively) compared with in the absence of both the diseases. Furthermore, the presence of both the diseases further significantly increased the mortality rate compared to the presence of each disease alone (HR 1.67, 95% CI: 1.65-1.69).In conclusion, this study found that the incidence of dementia was much higher in patients with T2D. CLD was associated with a modest increase in risk of dementia; however, there was no additive effect with T2D. In the population with dementia, however, the presence of CLD was associated with high mortality in patients with or without T2D.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMedicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCause of Death-
dc.subject.MESHCohort Studies-
dc.subject.MESHDementia/epidemiology-
dc.subject.MESHDementia/etiology-
dc.subject.MESHDementia/mortality-
dc.subject.MESHDiabetes Mellitus, Type 2/complications-
dc.subject.MESHEnd Stage Liver Disease/complications-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.titleImpact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHyun Min Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorKyungdo Han-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorJaetaek Kim-
dc.contributor.googleauthorBong-Soo Cha-
dc.identifier.doi10.1097/MD.0000000000008753-
dc.contributor.localIdA00068-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid29381970-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.citation.volume96-
dc.citation.number47-
dc.citation.startPagee8753-
dc.identifier.bibliographicCitationMedicine, Vol.96(47) : e8753, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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