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Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea.

 Jin Myoung Seok  ;  Hye-Jin Cho  ;  Suk-Won Ahn  ;  Eun Bin Cho  ;  Min Su Park  ;  In-Soo Joo  ;  Ha Young Shin  ;  Sun-Young Kim  ;  Byung-Jo Kim  ;  Jong Kuk Kim  ;  Joong-Yang Cho  ;  So-Young Huh  ;  Ohyun Kwon  ;  Kwang-Ho Lee  ;  Byoung Joon Kim  ;  Ju-Hong Min 
 MULTIPLE SCLEROSIS JOURNAL , Vol.23(13) : 1748-1756, 2017 
Journal Title
Issue Date
Neuromyelitis optica ; age of onset ; late-onset neuromyelitis optica ; neuromyelitis optica spectrum disorder ; seropositive neuromyelitis optica spectrum disorder
BACKGROUND: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). OBJECTIVE: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. METHODS: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated. RESULTS: Among a total of 147 patients (125 female; age of onset, 39.4 ± 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up ( r = 0.246, p = 0.003). CONCLUSION: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
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