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Staged development of long-lived T-cell receptor αβ TH17 resident memory T-cell population to Candida albicans after skin infection
DC Field | Value | Language |
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dc.contributor.author | 박창욱 | - |
dc.date.accessioned | 2018-07-20T12:00:22Z | - |
dc.date.available | 2018-07-20T12:00:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161627 | - |
dc.description.abstract | BACKGROUND: Candida albicans is a dimorphic fungus to which human subjects are exposed early in life, and by adulthood, it is part of the mycobiome of skin and other tissues. Neonatal skin lacks resident memory T (TRM) cells, but in adults the C albicans skin test is a surrogate for immunocompetence. Young adult mice raised under specific pathogen-free conditions are naive to C albicans and have been shown recently to have an immune system resembling that of neonatal human subjects. OBJECTIVE: We studied the evolution of the adaptive cutaneous immune response to Candida species. METHODS: We examined both human skin T cells and the de novo and memory immune responses in a mouse model of C albicans skin infection. RESULTS: In mice the initial IL-17-producing cells after C albicans infection were dermal γδ T cells, but by day 7, αβ TH17 effector T cells were predominant. By day 30, the majority of C albicans-reactive IL-17-producing T cells were CD4 TRM cells. Intravital microscopy showed that CD4 effector T cells were recruited to the site of primary infection and were highly motile 10 days after infection. Between 30 and 90 days after infection, these CD4 T cells became increasingly sessile, acquired expression of CD69 and CD103, and localized to the papillary dermis. These established TRM cells produced IL-17 on challenge, whereas motile migratory memory T cells did not. TRM cells rapidly clear an infectious challenge with C albicans more effectively than recirculating T cells, although both populations participate. We found that in normal human skin IL-17-producing CD4+ TRM cells that responded to C albicans in an MHC class II-restricted fashion could be identified readily. CONCLUSIONS: These studies demonstrate that C albicans infection of skin preferentially generates CD4+ IL-17-producing TRM cells, which mediate durable protective immunity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | St Louis, Mosby | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Staged development of long-lived T-cell receptor αβ TH17 resident memory T-cell population to Candida albicans after skin infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Dermatology | - |
dc.contributor.googleauthor | Chang Ook Park | - |
dc.contributor.googleauthor | Xiujun Fu | - |
dc.contributor.googleauthor | Xiaodong Jiang | - |
dc.contributor.googleauthor | Youdong Pan | - |
dc.contributor.googleauthor | Jessica E. Teague | - |
dc.contributor.googleauthor | Nicholas Collins | - |
dc.contributor.googleauthor | Tian Tian | - |
dc.contributor.googleauthor | John T. O'Malley | - |
dc.contributor.googleauthor | Ryan O. Emerson | - |
dc.contributor.googleauthor | Ji Hye Kim | - |
dc.contributor.googleauthor | Yookyung Jung | - |
dc.contributor.googleauthor | Rei Watanabe | - |
dc.contributor.googleauthor | Robert C. Fuhlbrigge | - |
dc.contributor.googleauthor | Francis R. Carbone | - |
dc.contributor.googleauthor | Thomas Gebhardt | - |
dc.contributor.googleauthor | Rachael A. Clark | - |
dc.contributor.googleauthor | Charles P. Lin | - |
dc.contributor.googleauthor | Thomas S. Kupper | - |
dc.identifier.doi | 10.1016/j.jaci.2017.09.042 | - |
dc.contributor.localId | A01716 | - |
dc.relation.journalcode | J01228 | - |
dc.identifier.eissn | 1097-6825 | - |
dc.identifier.pmid | 29128674 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0091674917317372 | - |
dc.subject.keyword | CD4(+) T(RM) | - |
dc.subject.keyword | Candida albicans | - |
dc.subject.keyword | IL-17 | - |
dc.subject.keyword | Resident memory T cells | - |
dc.subject.keyword | T(H)17 | - |
dc.subject.keyword | T(RM) | - |
dc.contributor.alternativeName | Park, Chang Ook | - |
dc.contributor.affiliatedAuthor | Park, Chang Ook | - |
dc.contributor.affiliatedAuthor | 박창욱 | - |
dc.citation.volume | 142 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 647 | - |
dc.citation.endPage | 662 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.142(2) : 647-662, 2018 | - |
dc.identifier.rimsid | 61650 | - |
dc.type.rims | ART | - |
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