226 246

Cited 27 times in

Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages (vol 55, pg 865, 2017)

DC Field Value Language
dc.contributor.author김희정-
dc.date.accessioned2018-07-20T11:59:38Z-
dc.date.available2018-07-20T11:59:38Z-
dc.date.issued2017-
dc.identifier.issn0095-1137-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161602-
dc.description.abstractThe diarrheal pathogen Clostridium difficile consists of at least six distinct evolutionary lineages. The RT017 lineage is anomalous, as strains only express toxin B, compared to strains from other lineages that produce toxins A and B and, occasionally, binary toxin. Historically, RT017 initially was reported in Asia but now has been reported worldwide. We used whole-genome sequencing and phylogenetic analysis to investigate the patterns of global spread and population structure of 277 RT017 isolates from animal and human origins from six continents, isolated between 1990 and 2013. We reveal two distinct evenly split sublineages (SL1 and SL2) of C. difficile RT017 that contain multiple independent clonal expansions. All 24 animal isolates were contained within SL1 along with human isolates, suggesting potential transmission between animals and humans. Genetic analyses revealed an overrepresentation of antibiotic resistance genes. Phylogeographic analyses show a North American origin for RT017, as has been found for the recently emerged epidemic RT027 lineage. Despite having only one toxin, RT017 strains have evolved in parallel from at least two independent sources and can readily transmit between continents.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Society for Microbiology-
dc.relation.isPartOfJOURNAL OF CLINICAL MICROBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHClostridium Infections/epidemiology-
dc.subject.MESHClostridium Infections/microbiology*-
dc.subject.MESHClostridium Infections/veterinary*-
dc.subject.MESHClostridium difficile/classification*-
dc.subject.MESHClostridium difficile/genetics*-
dc.subject.MESHClostridium difficile/isolation & purification-
dc.subject.MESHGenetic Variation*-
dc.subject.MESHGenome, Bacterial-
dc.subject.MESHGlobal Health-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Epidemiology-
dc.subject.MESHPhylogeny*-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHRibotyping*-
dc.subject.MESHSequence Analysis, DNA-
dc.titleComparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages (vol 55, pg 865, 2017)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorM. D. Cairns-
dc.contributor.googleauthorM. D. Preston-
dc.contributor.googleauthorC. L. Hall-
dc.contributor.googleauthorD. N. Gerding-
dc.contributor.googleauthorP. M. Hawkey-
dc.contributor.googleauthorH. Kato-
dc.contributor.googleauthorH. Kim-
dc.contributor.googleauthorE. J. Kuijper-
dc.contributor.googleauthorT. D. Lawley-
dc.contributor.googleauthorH. Pituch-
dc.contributor.googleauthorS. Reid-
dc.contributor.googleauthorB. Kullin-
dc.contributor.googleauthorT. V. Riley-
dc.contributor.googleauthorK. Solomon-
dc.contributor.googleauthorP. J. Tsai-
dc.contributor.googleauthorJ. S. Weese-
dc.contributor.googleauthorR. A. Stabler-
dc.contributor.googleauthorB. W. Wren-
dc.identifier.doi10.1128/JCM.01296-16-
dc.contributor.localIdA01219-
dc.relation.journalcodeJ01325-
dc.identifier.eissn1098-660X-
dc.identifier.pmid28031436-
dc.subject.keywordClostridium difficile-
dc.subject.keywordSNPs-
dc.subject.keywordantibiotic resistance-
dc.subject.keywordevolution-
dc.subject.keywordphylogenetics-
dc.subject.keywordphylogeny-
dc.subject.keywordribotype 017-
dc.subject.keywordsequencing-
dc.contributor.alternativeNameKim, Hee Jung-
dc.contributor.affiliatedAuthorKim, Heejung-
dc.citation.volume55-
dc.citation.number3-
dc.citation.startPage865-
dc.citation.endPage876-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MICROBIOLOGY, Vol.55(3) : 865-876, 2017-
dc.identifier.rimsid61626-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.