Cited 17 times in
Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정인경 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 차윤진 | - |
dc.contributor.author | 홍민희 | - |
dc.date.accessioned | 2018-07-20T11:58:37Z | - |
dc.date.available | 2018-07-20T11:58:37Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161573 | - |
dc.description.abstract | We investigated the concordance of programmed death-ligand 1 (PD-L1) expression between primary cancer at initial diagnosis and metastasis at recurrence in resected non-small cell lung cancer (NSCLC). PD-L1 expression was evaluated using the SP142 assay in 37 NSCLC patients with paired primary lung cancer and surgically resected metastases at recurrence. PD-L1 positivity was defined as immunohistochemistry (IHC) and also evaluated by RNA in situ hybridization (RISH). The concordance rate of PD-L1 between primaries and metastases and correlation with clinicopathological factors were analyzed. PD-L1 expression was higher in squamous cell carcinoma, wild-type EGFR, and smokers than in non-squamous carcinoma, mutant EGFR, and never smokers, respectively. PD-L1 positivity was observed in 18.9% of primaries and 21.6% of metastases. IHC demonstrated 78.4% concordance of PD-L1 positivity between primary and metastatic cancers. In 10.8% of cases, PD-L1 positivity was higher in primaries than in metastases, and vice versa in the remaining 10.8%. By PD-L1 RISH, 35.1% of primaries and 27.0% of metastases demonstrated PD-L1 positivity. There was 62.2% concordance in PD-L1 by RISH between the primaries and metastases. Our results thus highlight the clinical importance of replacing metastases with primary archival tissue, particularly when re-biopsy is difficult at recurrence. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Min Hee Hong | - |
dc.contributor.googleauthor | Manoj Gandhi | - |
dc.contributor.googleauthor | Shauna Levinson | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.identifier.doi | 10.18632/oncotarget.20254 | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03693 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A04393 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 29152077 | - |
dc.subject.keyword | RNA in situ hybridization | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | non-small cell lung cancer | - |
dc.subject.keyword | programmed death ligand-1 | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Jung, In Kyung | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.alternativeName | Hong, Min Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Jung, In Kyung | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Hong, Min Hee | - |
dc.citation.volume | 8 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 87234 | - |
dc.citation.endPage | 87243 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.8(50) : 87234-87243, 2017 | - |
dc.identifier.rimsid | 61601 | - |
dc.type.rims | ART | - |
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