Cited 2 times in
Highly preserved consensus gene modules in human papilloma virus 16 positive cervical cancer and head and neck cancers
DC Field | Value | Language |
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dc.contributor.author | 김기열 | - |
dc.contributor.author | 장향란 | - |
dc.contributor.author | 차인호 | - |
dc.date.accessioned | 2018-07-20T11:58:20Z | - |
dc.date.available | 2018-07-20T11:58:20Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161565 | - |
dc.description.abstract | In this study, we investigated the consensus gene modules in head and neck cancer (HNC) and cervical cancer (CC). We used a publicly available gene expression dataset, GSE6791, which included 42 HNC, 14 normal head and neck, 20 CC and 8 normal cervical tissue samples. To exclude bias because of different human papilloma virus (HPV) types, we analyzed HPV16-positive samples only. We identified 3824 genes common to HNC and CC samples. Among these, 977 genes showed high connectivity and were used to construct consensus modules. We demonstrated eight consensus gene modules for HNC and CC using the dissimilarity measure and average linkage hierarchical clustering methods. These consensus modules included genes with significant biological functions, including ATP binding and extracellular exosome. Eigengen network analysis revealed the consensus modules were highly preserved with high connectivity. These findings demonstrate that HPV16-positive head and neck and cervical cancers share highly preserved consensus gene modules with common potentially therapeutic targets. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Highly preserved consensus gene modules in human papilloma virus 16 positive cervical cancer and head and neck cancers | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.contributor.googleauthor | Ki-Yeol Kim | - |
dc.identifier.doi | 10.18632/oncotarget.23116 | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A03489 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 29371966 | - |
dc.subject.keyword | cervical cancer | - |
dc.subject.keyword | consensus module | - |
dc.subject.keyword | gene expression | - |
dc.subject.keyword | head and neck cancer | - |
dc.subject.keyword | multicancer therapy | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.alternativeName | Zhang, Xiang Lan | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.affiliatedAuthor | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | Zhang, Xiang Lan | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.citation.volume | 8 | - |
dc.citation.number | 69 | - |
dc.citation.startPage | 114031 | - |
dc.citation.endPage | 114040 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.8(69) : 114031-114040, 2017 | - |
dc.identifier.rimsid | 61594 | - |
dc.type.rims | ART | - |
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