Cited 39 times in
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2018-07-20T11:57:24Z | - |
dc.date.available | 2018-07-20T11:57:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161548 | - |
dc.description.abstract | Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2), which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis and lung metastasis and induces apoptosis by increasing the intracellular mature form of cathepsin B, whereas BAG2 expression induces metastasis by blocking the auto-cleavage processing of pro-cathepsin B via interaction with the propeptide region. BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis. Collectively, our results uncover BAG2 as a regulator of the oncogenic function of pro-cathepsin B and a potential diagnostic and therapeutic target that may reduce the burden of metastatic breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Kyung-Min Yang | - |
dc.contributor.googleauthor | Eunjin Bae | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Kyoungwha Pang | - |
dc.contributor.googleauthor | Yuna Park | - |
dc.contributor.googleauthor | Jinah Park | - |
dc.contributor.googleauthor | Jihee Lee | - |
dc.contributor.googleauthor | Akira Ooshima | - |
dc.contributor.googleauthor | Bora Park | - |
dc.contributor.googleauthor | Junil Kim | - |
dc.contributor.googleauthor | Yunshin Jung | - |
dc.contributor.googleauthor | Satoru Takahashi | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Seok Hee Park | - |
dc.contributor.googleauthor | Seong-Jin Kim | - |
dc.identifier.doi | 10.1016/j.celrep.2017.11.026 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 29212038 | - |
dc.subject.keyword | BAG2 | - |
dc.subject.keyword | TGN38 | - |
dc.subject.keyword | TNBC | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | cathepsin B | - |
dc.subject.keyword | metastasis | - |
dc.subject.keyword | tumorigenesis | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.citation.volume | 21 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2952 | - |
dc.citation.endPage | 2964 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.21(10) : 2952-2964, 2017 | - |
dc.identifier.rimsid | 61577 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.