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Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice

Authors
 Kyoung-Ho Pyo  ;  You-Won Lee  ;  Sang-Hoon Lee  ;  Chun-Feng Xin  ;  Ji-Hun Shin  ;  Eun-Hee Shin 
Citation
 NATURAL PRODUCT COMMUNICATIONS, Vol.12(1) : 73-78, 2017 
Journal Title
NATURAL PRODUCT COMMUNICATIONS
ISSN
 1934-578X 
Issue Date
2017
Abstract
The present study investigated the effect of peanut sprout extract (PSE) as a natural resveratrol supplement on chronic bacterial prostatitis (CBP) and estradiol- induced benign prostatic hyperplasia (BPH). PSE contained a high level of resveratrol (148.51 ± 3.05 μg/g), and was tested on the mouse models of CBP (induced by Escherichia coli 292 infection) and BPH (induced by treatment with β-estradiol and dihydrotestosterone). PSE toxicity was assessed on the basis of changes in body weight, alanine aminotransferase activity (an indicator of hepatotoxicity), and expression of the kidney injury marker KIM-1. The effects of PSE on the histopathology of prostate tissue, the proportion of neutrophils, and immune cell profiles in the blood and spleen were examined. PSE administration did not result in any toxicity but reduced the bacterial burden and histopathological changes in the prostate. In addition, lymphocytes (CD4+, CD8+, and CD19+) in the spleen were significantly increased after PSE administration in CBP mice, suggesting immune enhancement. PSE treatment of bone marrow–derived macrophages increased the expression of CD40, which is related to the pro-inflammatory function and host defense against pathogens. It is concluded that PSE would be a good supplement for the mitigation of prostate hyperplasia and prostatitis.

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Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice. Available from: https://www.researchgate.net/publication/312627301_Preventive_Effects_of_Resveratrol-enriched_Extract_of_Peanut_Sprout_on_Bacteria-_and_Estradiol-induced_Prostatitis_in_Mice [accessed Jun 27 2018].
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Pyo, Kyoung Ho(표경호) ORCID logo https://orcid.org/0000-0001-5428-0288
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161536
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