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Hyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients

DC FieldValueLanguage
dc.contributor.author김영삼-
dc.contributor.author이재길-
dc.contributor.author조윤수-
dc.date.accessioned2018-07-20T11:55:42Z-
dc.date.available2018-07-20T11:55:42Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161506-
dc.description.abstractBACKGROUND: To investigate natural killer (NK) cell activity, circulating cytokine level and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients. METHODS: Blood samples were collected <24 h after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. Serum cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured. RESULTS: The ICU group showed lower NK cell activity than the controls under all conditions and an absence of interferon (IFN)-γ. After adjusting for triglycerides, LDL- and HDL-cholesterol, and glucose, the ICU group exhibited lower serum levels of albumin and interleukin (IL)-12 and higher leukocyte counts and hs-CRP and IL-6 levels than the controls. Non-stimulated PBMCs from ICU patients secreted significantly greater amounts of IL-6 and IL-1β than the controls; however, the production of IL-6, TNF-α and IL-1β in response to LPS stimulation was significantly lower in the ICU group. CONCLUSIONS: Significant reductions in NK cell activity and serum IL-12 level, an absence of serum IFN-γ, and decreased cytokine production from LPS-stimulated PBMCs indicate the hyporesponsiveness of NK cells and an impaired early phase inflammatory response in critically ill patients (ClinicalTrials.gov NCT02565589 :).-
dc.description.statementOfResponsibilityopen-
dc.languageEngland-
dc.publisher1471-2172-
dc.relation.isPartOfBMC Immunology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorMinkyung Kim-
dc.contributor.googleauthorMinjoo Kim-
dc.contributor.googleauthorHana Jeong-
dc.contributor.googleauthorJey Sook Chae-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorJae Gil Lee-
dc.contributor.googleauthorYounsoo Cho-
dc.contributor.googleauthorJong Ho Lee-
dc.identifier.doi10.1186/s12865-017-0231-y-
dc.contributor.localIdA00707-
dc.contributor.localIdA03070-
dc.contributor.localIdA04682-
dc.relation.journalcodeJ03324-
dc.identifier.pmid29221433-
dc.subject.keywordCytokine-
dc.subject.keywordICU-
dc.subject.keywordInflammatory response-
dc.subject.keywordNK cell-
dc.subject.keywordPBMC-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameLee, Jae Gil-
dc.contributor.alternativeNameCho, Youn Soo-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorLee, Jae Gil-
dc.contributor.affiliatedAuthorCho, Youn Soo-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage48-
dc.identifier.bibliographicCitationBMC Immunology, Vol.18(1) : 48, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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