Cited 9 times in
Hyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 이재길 | - |
dc.contributor.author | 조윤수 | - |
dc.date.accessioned | 2018-07-20T11:55:42Z | - |
dc.date.available | 2018-07-20T11:55:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161506 | - |
dc.description.abstract | BACKGROUND: To investigate natural killer (NK) cell activity, circulating cytokine level and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients. METHODS: Blood samples were collected <24 h after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. Serum cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured. RESULTS: The ICU group showed lower NK cell activity than the controls under all conditions and an absence of interferon (IFN)-γ. After adjusting for triglycerides, LDL- and HDL-cholesterol, and glucose, the ICU group exhibited lower serum levels of albumin and interleukin (IL)-12 and higher leukocyte counts and hs-CRP and IL-6 levels than the controls. Non-stimulated PBMCs from ICU patients secreted significantly greater amounts of IL-6 and IL-1β than the controls; however, the production of IL-6, TNF-α and IL-1β in response to LPS stimulation was significantly lower in the ICU group. CONCLUSIONS: Significant reductions in NK cell activity and serum IL-12 level, an absence of serum IFN-γ, and decreased cytokine production from LPS-stimulated PBMCs indicate the hyporesponsiveness of NK cells and an impaired early phase inflammatory response in critically ill patients (ClinicalTrials.gov NCT02565589 :). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | England | - |
dc.publisher | 1471-2172 | - |
dc.relation.isPartOf | BMC IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Hyporesponsiveness of natural killer cells and impaired inflammatory responses in critically ill patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Minkyung Kim | - |
dc.contributor.googleauthor | Minjoo Kim | - |
dc.contributor.googleauthor | Hana Jeong | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Jae Gil Lee | - |
dc.contributor.googleauthor | Younsoo Cho | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1186/s12865-017-0231-y | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A03070 | - |
dc.contributor.localId | A04682 | - |
dc.relation.journalcode | J03324 | - |
dc.identifier.eissn | 1471-2172 | - |
dc.identifier.pmid | 29221433 | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | ICU | - |
dc.subject.keyword | Inflammatory response | - |
dc.subject.keyword | NK cell | - |
dc.subject.keyword | PBMC | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Lee, Jae Gil | - |
dc.contributor.alternativeName | Cho, Youn Soo | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Lee, Jae Gil | - |
dc.contributor.affiliatedAuthor | Cho, Youn Soo | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 48 | - |
dc.identifier.bibliographicCitation | BMC IMMUNOLOGY, Vol.18(1) : 48, 2017 | - |
dc.identifier.rimsid | 61412 | - |
dc.type.rims | ART | - |
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