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Cited 3 times in

MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana

DC FieldValueLanguage
dc.contributor.author유문영-
dc.date.accessioned2018-07-20T11:55:28Z-
dc.date.available2018-07-20T11:55:28Z-
dc.date.issued2017-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161501-
dc.description.abstractUbiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded Protein Sensing RING E3 ligase 1 (MPSR1) is an indispensable E3 ligase required for plant survival after protein-damaging stress. Under no stress, MPSR1 is prone to rapid degradation by the 26S proteasome, concealing its protein quality control (PQC) E3 ligase activity. Upon proteotoxic stress, MPSR1 directly senses incipient misfolded proteins and tethers ubiquitins for subsequent degradation. Furthermore, MPSR1 sustains the structural integrity of the proteasome complex at the initial stage of proteotoxic stress. Here, we suggest that the MPSR1 pathway is a constitutive mechanism for proteostasis under protein-damaging stress, as a front-line surveillance system in the cytoplasm.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNational Academy of Sciences-
dc.relation.isPartOfProceedings of the National Academy of Sciences of the United States of America-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHArabidopsis/genetics-
dc.subject.MESHArabidopsis/growth & development-
dc.subject.MESHArabidopsis/metabolism*-
dc.subject.MESHArabidopsis Proteins/genetics-
dc.subject.MESHArabidopsis Proteins/metabolism*-
dc.subject.MESHCytoplasm/metabolism-
dc.subject.MESHDNA, Plant-
dc.subject.MESHGene Expression Regulation, Plant-
dc.subject.MESHGenes, Plant/genetics-
dc.subject.MESHPhenotype-
dc.subject.MESHProteasome Endopeptidase Complex/metabolism-
dc.subject.MESHProtein Folding*-
dc.subject.MESHProtein Interaction Domains and Motifs-
dc.subject.MESHProteolysis-
dc.subject.MESHProteostasis*-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHSequence Analysis-
dc.subject.MESHSequence Analysis, RNA-
dc.subject.MESHStress, Psychological-
dc.subject.MESHTwo-Hybrid System Techniques-
dc.subject.MESHUbiquitin-Protein Ligases/genetics-
dc.subject.MESHUbiquitin-Protein Ligases/metabolism*-
dc.subject.MESHUbiquitins/metabolism-
dc.subject.MESHYeasts/genetics-
dc.titleMPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorJong Hum Kim,a,1 Seok Keun Cho,a,1 Tae Rin Oh,a Moon Young Ryu,a Seong Wook Yang,a,b,2 and Woo Taek Kima,2-
dc.identifier.doi10.1073/pnas.1713574114-
dc.contributor.localIdA05366-
dc.relation.journalcodeJ02550-
dc.identifier.eissn1091-6490-
dc.identifier.pmid29087340-
dc.subject.keywordE3 ligase-
dc.subject.keywordPQC-
dc.subject.keywordproteostasis-
dc.contributor.alternativeNameRyu, Moon Young-
dc.contributor.affiliatedAuthorRyu, Moon Young-
dc.citation.volume114-
dc.citation.number46-
dc.citation.startPageE10009-
dc.citation.endPageE10017-
dc.identifier.bibliographicCitationProceedings of the National Academy of Sciences of the United States of America, Vol.114(46) : E10009-E10017, 2017-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)

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