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DNA methylation-based age prediction from various tissues and body fluids

Authors
 Sang-Eun Jung  ;  Kyoung-Jin Shin  ;  Hwan Young Lee 
Citation
 BMB Reports, Vol.50(11) : 546-553, 2017 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2017
Keywords
Age prediction ; DNA methylation ; Forensic genetics
Abstract
Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many studies have reported age prediction models based on DNA methylation from various tissues and body fluids. Those models seem to be very promising because of their high prediction accuracies. In this review, the changes of age-associated DNA methylation and the age prediction models for various tissues and body fluids were examined, and then the applicability of the DNA methylation-based age prediction method to the forensic investigations was discussed. This will improve the understandings about DNA methylation markers and their potential to be used as biomarkers in the forensic field, as well as the clinical field.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161496
DOI
10.5483/BMBRep.2017.50.11.175
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과)
Yonsei Authors
신경진(Shin, Kyoung Jin) ; 이환영(Lee, Hwan Young) ; 정상은(Jung, Sang Eun)
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