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Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis

DC Field Value Language
dc.contributor.author김형표-
dc.contributor.author송민지-
dc.date.accessioned2018-07-20T11:54:25Z-
dc.date.available2018-07-20T11:54:25Z-
dc.date.issued2017-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161480-
dc.description.abstractRNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic factors. Here we report global Pol III expression/methylation profiles and molecular mechanisms of Pol III regulation that have not been as extensively studied, using nc886 as a representative Pol III gene. In a human mammary epithelial cell system that recapitulates early breast tumorigenesis, the fraction of actively transcribed Pol III genes increases reaching a plateau during immortalization. Hyper-methylation of Pol III genes inhibits Pol III binding to DNA via inducing repressed chromatin and is a determinant for the Pol III repertoire. When Pol III genes are hypo-methylated, MYC amplifies their transcription, regardless of its recognition DNA motif. Thus, Pol III expression during tumorigenesis is delineated by methylation and magnified by MYC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfONCOGENE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast/cytology-
dc.subject.MESHBreast/metabolism-
dc.subject.MESHCell Transformation, Neoplastic/genetics-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChromatin/genetics-
dc.subject.MESHChromatin/metabolism-
dc.subject.MESHDNA/genetics-
dc.subject.MESHDNA/metabolism-
dc.subject.MESHDNA Methylation-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHEpithelial Cells/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHProtein Binding-
dc.subject.MESHProto-Oncogene Proteins c-myc/genetics-
dc.subject.MESHRNA Polymerase III/metabolism-
dc.subject.MESHRNA, Untranslated/genetics-
dc.subject.MESHTranscription, Genetic-
dc.titleEpigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Environmental Medical Biology-
dc.contributor.googleauthorPark JL-
dc.contributor.googleauthorLee YS-
dc.contributor.googleauthorSong MJ-
dc.contributor.googleauthorHong SH-
dc.contributor.googleauthorAhn JH-
dc.contributor.googleauthorSeo EH-
dc.contributor.googleauthorShin SP-
dc.contributor.googleauthorLee SJ-
dc.contributor.googleauthorJohnson BH-
dc.contributor.googleauthorStampfer MR-
dc.contributor.googleauthorKim HP-
dc.contributor.googleauthorKim SY-
dc.contributor.googleauthorLee YS-
dc.identifier.doi10.1038/onc.2017.285-
dc.contributor.localIdA01163-
dc.contributor.localIdA02025-
dc.relation.journalcodeJ02413-
dc.identifier.eissn1476-5594-
dc.identifier.pmid28846112-
dc.identifier.urlhttp://www.nature.com/articles/onc2017285-
dc.contributor.alternativeNameKim, Hyoung Pyo-
dc.contributor.alternativeNameSong, Min Ji-
dc.contributor.affiliatedAuthorKim, Hyoung Pyo-
dc.contributor.affiliatedAuthorSong, Min Ji-
dc.citation.volume36-
dc.citation.number49-
dc.citation.startPage6793-
dc.citation.endPage6804-
dc.identifier.bibliographicCitationONCOGENE, Vol.36(49) : 6793-6804, 2017-
dc.identifier.rimsid61387-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers

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