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재발성/불응성 소아 급성림프모구백혈병 환자의 치료 경향 및 성적에 대한 다기관 후향적 관찰 연구
DC Field | Value | Language |
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dc.contributor.author | 유철주 | - |
dc.date.accessioned | 2018-07-20T11:54:14Z | - |
dc.date.available | 2018-07-20T11:54:14Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2233-5250 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161473 | - |
dc.description.abstract | Background: Although the overall survival of childhood acute lymphoblastic leukemia (ALL) approaches 85-90%, the prognosis of relapsed or refractory (R/R) ALL is grave. This study aimed to identify the treatment pattern, treatment response, and overall survival of these patients.Methods: We reviewed data of 64 patients with R/R ALL whose initial diagnosis of ALL had been made between 1 and 21 years of age. Patients who received clofarabine as part of an induction regimen were excluded. Relapsed patients were limited to those who relapsed after ≥2 prior induction regimens. Treatment patterns, response rates, and overall survival were analyzed.Results: Patients’ median age was 15.0 years (range, 6.0-25.0) at the diagnosis of R/R ALL. The most frequently used agents other than steroid were vincristine (54.0%), cytarabine (44.6%), and idarubicin (36.5%), while L-asparaginase was used in only one patient. The complete remission (CR) and overall response (OR) rates were 38.1 and 42.9%, respectively. Sixteen patients (25.4%) underwent allogeneic hematopoietic stem cell transplantation (HSCT). The 5-year overall survival was 6.7%. The survival of patients with HSCT was significantly higher compared with those without HSCT (35.2% vs 0%, P=0.0097). Among 14 patients who achieved CR or CR without platelet recovery (CRp) before HSCT, the 3-year survival was 46.9%. Conclusion: The survival of Korean patients with R/R childhood ALL was dismal despite a reasonable CR rate, whereas that of those who received HSCT after CR or CRp was excellent. More treatment options are needed to improve the overall outcome of R/R childhood ALL. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Clinical Pediatric Hematology-Oncology | - |
dc.relation.isPartOf | Clinical Pediatric Hematology-Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 재발성/불응성 소아 급성림프모구백혈병 환자의 치료 경향 및 성적에 대한 다기관 후향적 관찰 연구 | - |
dc.title.alternative | A Multicenter Retrospective Analysis on the Treatment Pattern and Outcome in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Keon Hee Yoo | - |
dc.contributor.googleauthor | Nak Gyun Chung | - |
dc.contributor.googleauthor | Bin Cho | - |
dc.contributor.googleauthor | Hyoung Jin Kang | - |
dc.contributor.googleauthor | Hee Young Shin | - |
dc.contributor.googleauthor | Ho Joon Im | - |
dc.contributor.googleauthor | Jong Jin Seo | - |
dc.contributor.googleauthor | Young Tak Lim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Soon Ki Kim | - |
dc.contributor.googleauthor | In-Sang Jeon | - |
dc.contributor.googleauthor | Hoon Kook | - |
dc.contributor.googleauthor | Hong Hoe Koo | - |
dc.identifier.doi | 10.15264/cpho.2017.24.2.101 | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J00605 | - |
dc.subject.keyword | Childhood | - |
dc.subject.keyword | Acute lymphoblastic leukemia | - |
dc.subject.keyword | Relapsed | - |
dc.subject.keyword | Refractory | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 106 | - |
dc.identifier.bibliographicCitation | Clinical Pediatric Hematology-Oncology, Vol.24(2) : 101-106, 2017 | - |
dc.identifier.rimsid | 61381 | - |
dc.type.rims | ART | - |
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