Cited 11 times in
Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
DC Field | Value | Language |
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dc.contributor.author | 박무석 | - |
dc.contributor.author | 송주한 | - |
dc.date.accessioned | 2018-07-20T11:53:54Z | - |
dc.date.available | 2018-07-20T11:53:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161464 | - |
dc.description.abstract | BACKGROUND: This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP. METHODS: We retrospectively reviewed medical records of 78 Korean PAP patients diagnosed between 1993 and 2014. Patients were classified into two groups according to the presence/absence of treatment (lavage). Clinical and laboratory features were compared between the two groups. RESULTS: Of the total 78 PAP patients, 60% were male and median age at diagnosis was 47.5 years. Fifty three percent were ever smokers (median 22 pack-years) and 48% had a history of dust exposure (metal 26.5%, stone or sand 20.6%, chemical or paint 17.7%, farming dust 14.7%, diesel 14.7%, textile 2.9%, and wood 2.9%). A history of cigarette smoking or dust exposure was present in 70.5% of the total PAP patients, with 23% having both of them. Patients who underwent lavage (n = 38) presented symptoms more frequently (38/38 [100%] vs. 24/40 [60%], P < 0.001) and had significantly lower PaO2 and DLCO with higher D(A-a)O2 at the onset of disease than those without lavage (n = 40) (P = 0.006, P < 0.001, and P = 0.036, respectively). Correspondingly, the distribution of disease severity score (DSS) differed significantly between the two groups (P = 0.001). Based on these, when the total patients were categorized according to DSS (low DSS [DSS 1-2] vs. high DSS [DSS 3-5]), smoking status differed significantly between the two groups with the proportion of current smokers significantly higher in the high DSS group (11/22 [50%] vs. 7/39 [17.9%], P = 0.008). Furthermore, current smokers had meaningfully higher DSS and serum CEA levels than non-current smokers (P = 0.011 and P = 0.031), whereas no difference was found between smokers and non-smokers. Regarding type of exposed dust, farming dust was significantly associated with more severe form of PAP (P = 0.004). CONCLUSION: A considerable proportion of PAP patients had a history of cigarette smoking and/or dust exposure, suggestive of their possible roles in the development of PAP. Active cigarette smoking at the onset of PAP is associated with the severity of PAP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC PULMONARY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ji An Hwang | - |
dc.contributor.googleauthor | Joo Han Song | - |
dc.contributor.googleauthor | Jung Hoon Kim | - |
dc.contributor.googleauthor | Man Pyo Chung | - |
dc.contributor.googleauthor | Dong Soon Kim | - |
dc.contributor.googleauthor | Jin Woo Song | - |
dc.contributor.googleauthor | Young Whan Kim | - |
dc.contributor.googleauthor | Sun Mi Choi | - |
dc.contributor.googleauthor | Seung Ick Cha | - |
dc.contributor.googleauthor | Soo Taek Uh | - |
dc.contributor.googleauthor | Choon-Sik Park | - |
dc.contributor.googleauthor | Sung Hwan Jeong | - |
dc.contributor.googleauthor | Yong Bum Park | - |
dc.contributor.googleauthor | Hong Lyeol Lee | - |
dc.contributor.googleauthor | Jong Wook Shin | - |
dc.contributor.googleauthor | Eun Joo Lee | - |
dc.contributor.googleauthor | Yangjin Jegal | - |
dc.contributor.googleauthor | Hyun Kyung Lee | - |
dc.contributor.googleauthor | Jong Sun Park | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.identifier.doi | 10.1186/s12890-017-0493-4 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02062 | - |
dc.relation.journalcode | J00375 | - |
dc.identifier.eissn | 1471-2466 | - |
dc.identifier.pmid | 29162083 | - |
dc.subject.keyword | Disease severity | - |
dc.subject.keyword | Dust exposure | - |
dc.subject.keyword | Pulmonary alveolar proteinosis | - |
dc.subject.keyword | Smoking | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Song, Joo Han | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Song, Joo Han | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 147 | - |
dc.identifier.bibliographicCitation | BMC PULMONARY MEDICINE, Vol.17(1) : 147, 2017 | - |
dc.identifier.rimsid | 61372 | - |
dc.type.rims | ART | - |
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