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Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery

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dc.contributor.author김학선-
dc.date.accessioned2018-07-20T11:53:37Z-
dc.date.available2018-07-20T11:53:37Z-
dc.date.issued2017-
dc.identifier.issn1203-6765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161456-
dc.description.abstractPURPOSE: Control of persistent pain following spinal surgery is an unmet clinical need. This study compared the efficacy and safety of buprenorphine transdermal system (BTDS) to oral tramadol/acetaminophen (TA) in Korean patients with persistent, moderate pain following spinal surgery. METHODS: Open-label, interventional, randomized multicenter study. Adults with persistent postoperative pain (Numeric Rating Scale [NRS] ≥ 4 at 14-90 days postsurgery) were enrolled. Patients received once-weekly BTDS (n = 47; 5 μg/h titrated to 20 μg/h) or twice-daily TA (n = 40; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks. The study compared pain reduction with BTDS versus TA at week 6. Quality of life (QoL), treatment satisfaction, medication compliance, and adverse events (AEs) were assessed. FINDINGS: At week 6, both groups reported significant pain reduction (mean NRS change: BTDS -2.02; TA -2.76, both P < 0.0001) and improved QoL (mean EQ-5D index change: BTDS 0.10; TA 0.19, both P < 0.05). The BTDS group achieved better medication compliance (97.8% versus 91.0%). Incidence of AEs (26.1% versus 20.0%) and adverse drug reactions (20.3% versus 16.9%) were comparable between groups. IMPLICATIONS: For patients with persistent pain following spinal surgery, BTDS is an alternative to TA for reducing pain and supports medication compliance. This trial is registered with Clinicaltrials.gov: NCT01983111.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHindawi Publishing Corporation-
dc.relation.isPartOfPAIN RESEARCH & MANAGEMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetaminophen/administration & dosage-
dc.subject.MESHAcetaminophen/therapeutic use*-
dc.subject.MESHAdministration, Cutaneous-
dc.subject.MESHAged-
dc.subject.MESHAnalgesics, Opioid/administration & dosage-
dc.subject.MESHAnalgesics, Opioid/therapeutic use-
dc.subject.MESHBuprenorphine/administration & dosage-
dc.subject.MESHBuprenorphine/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHQuality of Life-
dc.subject.MESHSpine/surgery*-
dc.subject.MESHTramadol/administration & dosage-
dc.subject.MESHTramadol/therapeutic use*-
dc.titleEfficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Orthopedic Surgery-
dc.contributor.googleauthorJae Hyup Lee-
dc.contributor.googleauthorJin-Hyok Kim-
dc.contributor.googleauthorJin-Hwan Kim-
dc.contributor.googleauthorHak-Sun Kim-
dc.contributor.googleauthorWoo-Kie Min-
dc.contributor.googleauthorYe-Soo Park-
dc.contributor.googleauthorKyu-Yeol Lee-
dc.contributor.googleauthorJung-Hee Lee-
dc.identifier.doi10.1155/2017/2071494-
dc.contributor.localIdA01093-
dc.relation.journalcodeJ03097-
dc.identifier.eissn1918-1523-
dc.identifier.pmid29056859-
dc.contributor.alternativeNameKim, Hak Sun-
dc.contributor.affiliatedAuthorKim, Hak Sun-
dc.citation.volume2017-
dc.citation.startPage2071494-
dc.identifier.bibliographicCitationPAIN RESEARCH & MANAGEMENT, Vol.2017 : 2071494, 2017-
dc.identifier.rimsid61364-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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