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Oncologic Outcomes and Predictive Factors for Recurrence Following Robot-Assisted Radical Cystectomy for Urothelial Carcinoma: Multicenter Study from Korea

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dc.contributor.author나군호-
dc.date.accessioned2018-07-20T11:53:22Z-
dc.date.available2018-07-20T11:53:22Z-
dc.date.issued2017-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161451-
dc.description.abstractThe aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis. Logistic regression models were used to determine predictors of recurrence. Median follow-up was 33 months (interquartile range [IQR], 7-50). The numbers of patients with organ-confined and lymph node (LN)-positive disease were 237 (68.4%) and 68 (19.7%), respectively. LN density (1-20 vs. > 20) was 13.6% and 6.1%, with a median of 17 nodes removed (IQR, 9-23). In logistic regression analysis, type of LN dissection, and pathologic tumor stage were significant predictors of cancer recurrence and death from cancer. Local, distal recurrence and secondary UC occurred in 7 (2.0%), 53 (15.3%), and 4 (1.2%) patients, respectively. The 5-year overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were 78%, 84%, and 73%, respectively. At last follow-up, RFS for extended pelvic LN dissection vs. standard pelvic LN dissection was 70% and 47% (P = 0.038). In addition, at last follow-up, LN density (0 vs. 1-20 vs. over 20) was 67%, 41%, and 29%, respectively (P < 0.001). Patients undergoing RARC in this multi-institutional cohort demonstrated intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns that were not unusual.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Transitional Cell/mortality-
dc.subject.MESHCarcinoma, Transitional Cell/pathology*-
dc.subject.MESHCarcinoma, Transitional Cell/surgery-
dc.subject.MESHCystectomy-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLogistic Models-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRobotic Surgical Procedures/methods*-
dc.subject.MESHTertiary Care Centers-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUrinary Bladder Neoplasms/mortality-
dc.subject.MESHUrinary Bladder Neoplasms/pathology*-
dc.subject.MESHUrinary Bladder Neoplasms/surgery-
dc.titleOncologic Outcomes and Predictive Factors for Recurrence Following Robot-Assisted Radical Cystectomy for Urothelial Carcinoma: Multicenter Study from Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorJi Sung Shim-
dc.contributor.googleauthorTae Gyun Kwon-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorYoung Goo Lee-
dc.contributor.googleauthorJi Youl Lee-
dc.contributor.googleauthorByong Chang Jeong-
dc.contributor.googleauthorJae Yoon Kim-
dc.contributor.googleauthorJong Hyun Pyun-
dc.contributor.googleauthorSung Gu Kang-
dc.contributor.googleauthorSeok Ho Kang-
dc.identifier.doi10.3346/jkms.2017.32.10.1662-
dc.contributor.localIdA01227-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid28875611-
dc.subject.keywordBladder Cancer-
dc.subject.keywordOutcomes-
dc.subject.keywordRadical Cystectomy-
dc.subject.keywordRecurrence-
dc.subject.keywordUrothelial Carcinoma-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.citation.volume32-
dc.citation.number10-
dc.citation.startPage1662-
dc.citation.endPage1668-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(10) : 1662-1668, 2017-
dc.identifier.rimsid61360-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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