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Tracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application

DC FieldValueLanguage
dc.contributor.author김원식-
dc.contributor.author성학준-
dc.contributor.author신승호-
dc.date.accessioned2018-07-20T08:45:20Z-
dc.date.available2018-07-20T08:45:20Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161385-
dc.description.abstractAlthough there are various methods for tracheal reconstruction, such as a simple approximation with suturing and coverage with adjacent soft tissue or muscle, large defects >50% of the tracheal length still present a clinical challenge. Tissue engineering, a recent promising way to possibly resolve this problem, requires a long preparatory period for stem cell seeding on a scaffold and relatively invasive procedures for stem cell harvesting. As an alternative, we used a vascularized myofascial flap for tracheal reconstruction. In four porcine models, the deep inferior epigastric perforator (DIEP) was used in two and the superior epigastric artery perforator (SEAP) in two. Transformation of the surface of the transplanted myofascial flap was analyzed in the airway environment. The flaps failed in the DIEP group due to venous congestion. At 12 weeks postoperatively, none of SEAP group showed any signs of respiratory distress; the inner surface of the implant exhibited stratified squamous epithelium with sparse cilia. In the clinical setting, a patient who underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in good health with no respiratory distress symptoms.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfScientific Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorWon Shik Kim-
dc.contributor.googleauthorJae Won Chang-
dc.contributor.googleauthorWoo Soon Jang-
dc.contributor.googleauthorYoung Joon Seo-
dc.contributor.googleauthorMi-Lan Kang-
dc.contributor.googleauthorHak-Joon Sung-
dc.contributor.googleauthorDa Hee Kim-
dc.contributor.googleauthorJung Min Kim-
dc.contributor.googleauthorJae Hong Park-
dc.contributor.googleauthorMyung Jin Ban-
dc.contributor.googleauthorGina Na-
dc.contributor.googleauthorSeung Ho Shin-
dc.contributor.googleauthorHyung Kwon Byeon-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorSe-Heon Kim-
dc.contributor.googleauthorHong Koo Baik-
dc.contributor.googleauthorEun Chang Choi-
dc.identifier.doi10.1038/s41598-017-10733-z-
dc.contributor.localIdA00765-
dc.contributor.localIdA01958-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28855683-
dc.contributor.alternativeNameKim, Won Shik-
dc.contributor.alternativeNameSung, Hak-Joon-
dc.contributor.affiliatedAuthorKim, Won Shik-
dc.contributor.affiliatedAuthorSung, Hak-Joon-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage10022-
dc.identifier.bibliographicCitationScientific Reports, Vol.7(1) : 10022, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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