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Mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses for the treatment of meibomian gland dysfunction

Authors
 Hun Lee  ;  Minseo Kim  ;  Si Yoon Park  ;  Eung Kweon Kim  ;  Kyoung Yul Seo  ;  Tae‐im Kim 
Citation
 Clinical & Experimental Optometry, Vol.100(6) : 598-602, 2017 
Journal Title
 Clinical & Experimental Optometry 
Issue Date
2017
MeSH
Adult ; Aged ; Combined Modality Therapy ; Conjunctiva/physiopathology ; Cornea/physiopathology ; Dry Eye Syndromes/physiopathology ; Dry Eye Syndromes/therapy* ; Eyelid Diseases/physiopathology ; Eyelid Diseases/therapy* ; Eyelids/physiopathology ; Female ; Fluorophotometry ; Humans ; Hyperthermia, Induced/methods* ; Interferometry ; Light ; Male ; Massage* ; Mechanical Phenomena ; Meibomian Glands/physiopathology* ; Middle Aged ; Prospective Studies ; Surveys and Questionnaires ; Tears/chemistry
Keywords
interferometer ; mechanical meibomian gland squeezing ; meibomian gland dysfunction ; meibomian gland squeezing forceps ; tear film lipid layer thickness
Abstract
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment. RESULTS: There were significant improvements in TBUT, corneal and conjunctival fluorescein staining scores, lid margin abnormality, meibum quality and expressibility, OSDI and MGD stage after mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses (p < 0.001 for TBUT, corneal fluorescein staining scores, Dry Eye Workshop score, Oxford staining score, lid margin abnormality, meibum quality, expressibility, OSDI and MGD stage and p = 0.001 for conjunctival fluorescein staining scores). There were no significant differences in lipid layer thickness or interferometer-derived parameters before treatment and after one month of treatment. Palpebral conjunctival erosion detected after the squeezing treatment resolved spontaneously in all participants. CONCLUSIONS: Mechanical squeezing of meibomian glands combined with eyelid scrubs and warm compresses can provide clinical benefits without serious adverse events.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161380
DOI
10.1111/cxo.12532
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
김응권(Kim, Eung Kweon) ; 김태임(Kim, Tae Im) ; 서경률(Seo, Kyuong Yul)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/cxo.12532
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