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Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improving Survival of Lymphoma trial

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dc.contributor.author김진석-
dc.date.accessioned2018-07-20T08:42:17Z-
dc.date.available2018-07-20T08:42:17Z-
dc.date.issued2017-
dc.identifier.issn2287-979X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161367-
dc.description.abstractBACKGROUND: Rituximab plus cyclophosphamide, vincristine, and prednisone (R-CVP) is one of the effective chemotherapeutic regimens for patients with advanced stage marginal zone lymphoma (MZL). However, prognostic factors that affect the outcome of treatment for MZL are not well understood. METHODS: Between August 2006 and June 2013, patients with newly diagnosed stage III and IV MZL treated with R-CVP as a first-line therapy from 15 institutions were retrospectively analyzed. Patients' clinical and laboratory data at diagnosis were collected by review of medical records. RESULTS: A total of 80 patients were analyzed. Bone marrow involvement was observed in 30% cases. Twelve patients (15%) had nodal MZL, and 41.3% patients exhibited multiple mucosa-associated lymphoma tissue sites. Overall response rate was 91.3%, including 73.8% achieving complete response. Advanced MZL patients treated with R-CVP showed a 3-year progression-free survival (PFS) rate of 69.6%. Prognostic markers significantly affecting PFS in univariate analysis were platelet to lymphocyte ratio (PLR, <95 vs. ≥95, P=0.014), serum albumin (≤3.9 vs. >3.9 g/dL, P=0.008), and the International Prognostic Index (IPI) score (1 vs. 2-4, P=0.032). In multivariate analysis, only PLR (<95 vs. ≥95, HR 0.367, 95% CI, 0.139-0.971, P=0.043) was an independent risk factor for PFS. CONCLUSION: PLR ≥95 at diagnosis is an independent prognostic marker for PFS in advanced stage MZL patients treated with R-CVP. This marker may aid clinicians in predicting the response to R-CVP chemotherapy in stage III and IV MZL patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorea Society of Hematology-
dc.relation.isPartOfBLOOD RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePlatelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improving Survival of Lymphoma trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJeongkuk Seo-
dc.contributor.googleauthorWon Seog Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorSeok Jin Kim-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorJun Shik Hong-
dc.contributor.googleauthorGyeong-Won Lee-
dc.contributor.googleauthorSung Yong Oh-
dc.contributor.googleauthorJi-Hyun Lee-
dc.contributor.googleauthorDok Hyun Yoon-
dc.contributor.googleauthorWon-Sik Lee-
dc.contributor.googleauthorHyo Jung Kim-
dc.contributor.googleauthorJae-Yong Kwak-
dc.contributor.googleauthorHye Jin Kang-
dc.contributor.googleauthorJae-Cheol Jo-
dc.contributor.googleauthorYong Park-
dc.contributor.googleauthorHo Sup Lee-
dc.contributor.googleauthorHyo-Jin Kim-
dc.contributor.googleauthorCheolwon Suh-
dc.identifier.doi10.5045/br.2017.52.3.200-
dc.contributor.localIdA01017-
dc.relation.journalcodeJ00346-
dc.identifier.eissn2288-0011-
dc.identifier.pmid29043235-
dc.subject.keywordMarginal zone lymphoma-
dc.subject.keywordPLR-
dc.subject.keywordPrognosis-
dc.subject.keywordR-CVP-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.citation.volume52-
dc.citation.number3-
dc.citation.startPage200-
dc.citation.endPage206-
dc.identifier.bibliographicCitationBLOOD RESEARCH, Vol.52(3) : 200-206, 2017-
dc.identifier.rimsid61285-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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