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Effect of yttrium-90 radioembolization on outcomes in Asian patients with early to advanced stage hepatocellular carcinoma

Authors
 Hyun Young Woo  ;  Do Young Kim  ;  Jeong Heo  ;  Chang Won Kim  ;  Suk Kim  ;  Ki Tae Yoon  ;  Won Lim  ;  Young Mi Hong  ;  Jong Yun Won  ;  Sangheun Lee  ;  Kwang Hyub Han  ;  Mong Cho 
Citation
 Hepatology Research, Vol.47(5) : 387-397, 2017 
Journal Title
 Hepatology Research 
ISSN
 1386-6346 
Issue Date
2017
Keywords
hepatocellular carcinoma ; radioembolization ; yttrium-90
Abstract
AIM: The aim of this study was to investigate the effect of yttrium-90 radioembolization on the outcome of Asian patients with early to advanced stage hepatocellular carcinoma (HCC). METHODS: Sixty-two patients were screened and 50 patients (80.6%) were eligible. Response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST), and overall survival was estimated using the Kaplan-Meier method. RESULTS: The Barcelona Clinic Liver Cancer (BCLC) stage was A in 40% of patients, B in 24%, and C in 36%; 66% of patients had hepatitis B virus infections. According to RECIST criteria, partial responses occurred in 40% of patients, and stable disease was achieved in 46%. Tumor response was significantly associated with BCLC stage (P = 0.003). The median overall time to progression was 5.8 months (range, 0.9-46.1 months). Follow-up treatments after radioembolization were carried out in 31 patients due to remnant HCC (n = 18) or HCC progression (n = 13). The median overall survival was 40.9 months (95% confidence interval, 10.2-71.6 months). Treatment was tolerable except for one lung toxicity and two hepatic toxicities. CONCLUSION: Yttrium-90 radioembolization appears to be well tolerated and effective in Asian patients with BCLC stage A-C HCC. Follow-up treatments after radioembolization can be safely provided.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161300
DOI
10.1111/hepr.12759
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김도영(Kim, Do Young)
원종윤(Won, Jong Yun)
한광협(Han, Kwang Hyup)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.12759
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