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Dapsone as a potential treatment option for Henoch-Schönlein Purpura (HSP)

Authors
 Keum Hwa Lee  ;  Jae Hyon Park  ;  Dong Hyun Kim  ;  Ji min Hwang  ;  Go eun Lee  ;  Jae Seok Hyun  ;  Sung Taik Heo  ;  Ji Hoon Choi  ;  Min woo Kim  ;  Min hye Kim  ;  Seong Il Kim  ;  Michael Eisenhut  ;  Andreas Kronbichler  ;  Jae Il Shin 
Citation
 Medical Hypotheses, Vol.108 : 42-45, 2017 
Journal Title
 Medical Hypotheses 
ISSN
 0306-9877 
Issue Date
2017
Keywords
Dapsone ; Henoch-Schönlein Purpura (HSP) ; Immunoglobulin A (IgA) ; Interleukin-8 (IL-8) ; Small vessel vasculitis
Abstract
Henoch-Schönlein Purpura (HSP, IgA vasculitis) is an immunoglobulin A (IgA) mediated disorder characterized by systemic vasculitis with variable presentation, frequently affecting the skin, mucous membrane, joints, kidneys, and rarely lungs and the central nervous system. Interestingly, enhanced production of interleukin-8 (IL-8) levels are found during active disease and increased levels have been reported in supernatants from human umbilical venous endothelial cells after stimulation with sera from patients affected by HSP. While corticosteroid therapy is currently the recommended treatment for HSP, dapsone, an anti-leprosy agent, has also recently been suggested to have therapeutic efficacy due to its ability to suppress IL-8. Moreover, in addition to IL-8 suppression, dapsone has been reported to exert various anti-inflammatory effects by inhibiting the generation of toxic free radicals, myeloperoxidase mediated halogenation that converts H2O2 to HOCl, leukocyte chemotaxis, production of tumor necrosis factor, and other anti-inflammatory molecules. This review aims to provide a solid hypothesis for the pathogenesis of vasculitis in HSP. Moreover, we highlight potential mechanistic actions of dapsone in hopes that dapsone may be considered as an alternative viable treatment for patients affected by HSP.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161287
DOI
10.1016/j.mehy.2017.07.018
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
신재일(Shin, Jae Il) ; 이금화(Lee, Geum Hwa)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0306987717304814
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