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Dysregulated expression of homeobox family genes may influence survival outcomes of patients with epithelial ovarian cancer: analysis of data from The Cancer Genome Atlas

DC FieldValueLanguage
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author남은지-
dc.contributor.author어경진-
dc.contributor.author이정윤-
dc.date.accessioned2018-07-20T08:33:42Z-
dc.date.available2018-07-20T08:33:42Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161285-
dc.description.abstractHomeobox (HOX) family genes encode key transcription factors for embryogenesis and may be correlated with carcinogenesis. The aim of this study was to elucidate whether aberrant expression of HOX genes influences outcomes in epithelial ovarian cancer (EOC). Gene expression data and clinicopathologic information from 630 patients with EOC were downloaded from The Cancer Genome Atlas database. We explored correlations between expression levels of HOX gene family members and clinicopathological variables. Higher expression of HOXA1, A4, A5, A7, A10, A11, B13, C13, D1, and D3 was associated with advanced FIGO stage. Suboptimal residual disease after debulking surgery was significantly correlated with higher expression of HOXB9, B13, and C13. Additionally, patients with high expression of HOXC6 and C11 were significantly more likely to have poor performance status. Overall survival was significantly shorter in patients with high, rather than low, expression of two HOX genes (HOXA10 and B3), and significantly longer in patients with high rather than low HOXC5 expression. Dysregulated expression of the HOXA10, B3, and C5 was significantly correlated with overall survival in EOC patients. HOX gene expression levels are potentially useful as a prognostic indicator in EOC, and HOX genes may represent a novel and promising target for anticancer therapeutics.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDysregulated expression of homeobox family genes may influence survival outcomes of patients with epithelial ovarian cancer: analysis of data from The Cancer Genome Atlas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorKyung Jin Eoh-
dc.contributor.googleauthorHee Jung Kim-
dc.contributor.googleauthorJung-Yun Lee-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.18632/oncotarget.19771-
dc.contributor.localIdA00526-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA04842-
dc.contributor.localIdA04638-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid29050303-
dc.subject.keywordTCGA-
dc.subject.keywordcarcinogenesis-
dc.subject.keywordepithelial ovarian cancer-
dc.subject.keywordhomeobox genes-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNameEoh, Kyung Jin-
dc.contributor.alternativeNameLee, Jung-Yun-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorEoh, Kyung Jin-
dc.contributor.affiliatedAuthorLee, Jung-Yun-
dc.citation.volume8-
dc.citation.number41-
dc.citation.startPage70579-
dc.citation.endPage70585-
dc.identifier.bibliographicCitationONCOTARGET , Vol.8(41) : 70579-70585, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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