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Risk factors for mortality in patients with low lactate level and septic shock

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dc.contributor.author구남수-
dc.contributor.author김용찬-
dc.contributor.author김은진-
dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author송제은-
dc.contributor.author오동현-
dc.contributor.author정수진-
dc.contributor.author정우용-
dc.contributor.author정인영-
dc.contributor.author최준용-
dc.date.accessioned2018-07-20T08:33:20Z-
dc.date.available2018-07-20T08:33:20Z-
dc.date.issued2017-
dc.identifier.issn1684-1182-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161282-
dc.description.abstractBACKGROUND: According to the new definition of septic shock, vasopressor therapy and hyperlactatemia are essential for diagnosis. However, there is controversy regarding the cutoff value for lactate, and prognostic factors in patients with septic shock and hypolactatemia. This study evaluated the prognostic significance of the cutoff value for lactate level in septic shock patients. METHODS: The retrospective observational cohort study enrolled 1043 patients aged ≥18 years who meet the revised definition of septic shock. Clinical outcomes of patients with hyperlactatemia were compared with hypolactatemia. RESULTS: Of the 1022 eligible patients, 369 had an arterial lactate level ≤2 mmol/L. More patients in the high lactate group had poor prognosis than in the low lactate group. A high Sequential Organ Failure Assessment score (SOFA) score group was significant (p < 0.001) in predicting lactate levels. On the subgroup analysis of risk factors affecting mortality in the low lactate group, high Acute Physiology And Chronic Health Evaluation Ⅱ (APACHEⅡ) score (p = 0.003), high C-reactive protein (p = 0.034), and chronic heart failure (p = 0.001) were independently associated with 28-day mortality. CONCLUSION: Arterial lactate is a very reliable diagnostic and prognostic predictor of septic shock. However, despite low arterial lactate, patients with a high APACHEⅡ score, high C-reactive protein levels, and chronic heart failure had a poorer prognosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Chinese-
dc.publisherElsevier for the Taiwan Society of Microbiology-
dc.relation.isPartOfJournal of Microbiology, Immunology and Infection-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRisk factors for mortality in patients with low lactate level and septic shock-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDong Hyun Oh-
dc.contributor.googleauthorMoo Hyun Kim-
dc.contributor.googleauthorWoo Yong Jeong-
dc.contributor.googleauthorYong Chan Kim-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorJe Eun Song-
dc.contributor.googleauthorIn Young Jung-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1016/j.jmii.2017.08.009-
dc.contributor.localIdA00189-
dc.contributor.localIdA00752-
dc.contributor.localIdA00823-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA02059-
dc.contributor.localIdA02361-
dc.contributor.localIdA03638-
dc.contributor.localIdA04670-
dc.contributor.localIdA03695-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ01595-
dc.identifier.eissn1995-9133-
dc.identifier.pmid28923305-
dc.subject.keywordAPACHEⅡ-
dc.subject.keywordC-reactive protein-
dc.subject.keywordChronic heart failure-
dc.subject.keywordLactate-
dc.subject.keywordSOFA score-
dc.subject.keywordScore-
dc.subject.keywordSeptic shock-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Yong Chan-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameSong, Je Eun-
dc.contributor.alternativeNameOh, Dong Hyun-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameJeong, Wooyong-
dc.contributor.alternativeNameJung, In Young-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Yong Chan-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorSong, Je Eun-
dc.contributor.affiliatedAuthorOh, Dong Hyun-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorJeong, Wooyong-
dc.contributor.affiliatedAuthorJung, In Young-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.citation.startPageepub.-
dc.identifier.bibliographicCitationJournal of Microbiology, Immunology and Infection : epub., 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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