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Impact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer

DC FieldValueLanguage
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author이강영-
dc.contributor.author조민수-
dc.contributor.author한정희-
dc.contributor.author허혁-
dc.date.accessioned2018-07-20T08:31:56Z-
dc.date.available2018-07-20T08:31:56Z-
dc.date.issued2017-
dc.identifier.issn0171-5216-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161269-
dc.description.abstractPURPOSE: The prognostic nutritional index (PNI) has been reported to be a predictive marker for surgical outcomes and prognosis in gastrointestinal malignancies. In this study, we aimed to identify the impact of preoperative PNI on the recovery and long-term oncologic outcome of patients with colorectal cancer (CRC). METHODS: A total of 3569 patients who underwent curative resection for CRC were enrolled, and their medical records were analyzed retrospectively. Preoperative PNI was calculated as 10× serum albumin concentration (g/dL) + 0.005 × total lymphocyte count (/mm3). The occurrence of postoperative complications, duration of hospital stay, disease-free survival, and overall survival were analyzed according to the preoperative PNI. In addition, PNI was compared according to the status of pathologic factors. RESULTS: The postoperative complication rate and postoperative duration of hospital stay increased significantly as PNI increased. Patients with a lower PNI showed a worse survival outcome. Increased depth of tumor invasion, presence of distant metastasis, and poorer histologic grade were associated with a lower PNI. The cut-point of preoperative PNI was calculated as 50, and patients with PNI > 50 showed a markedly better survival outcome. Furthermore, patients with PNI > 50 showed better results in postoperative complication rate and postoperative duration of hospital stay. CONCLUSION: Preoperative PNI is a simple and efficient indicator (cut-point 50) for estimating the recovery and oncologic outcome of patients. A low PNI was associated with increased occurrence of postoperative complications, prolonged hospital stay, poor oncologic outcome, and aggressive tumor phenotypes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, German-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHColorectal Neoplasms/mortality*-
dc.subject.MESHColorectal Neoplasms/pathology*-
dc.subject.MESHColorectal Neoplasms/surgery-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Assessment*-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleImpact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorGyoung Tae Noh-
dc.contributor.googleauthorJeonghee Han-
dc.contributor.googleauthorMin Soo Cho-
dc.contributor.googleauthorHyuk Hur-
dc.contributor.googleauthorByung Soh Min-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorNam Kyu Kim-
dc.identifier.doi10.1007/s00432-017-2366-x-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA02640-
dc.contributor.localIdA03817-
dc.contributor.localIdA05065-
dc.contributor.localIdA04373-
dc.relation.journalcodeJ01283-
dc.identifier.eissn1432-1335-
dc.identifier.pmid28243747-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00432-017-2366-x-
dc.subject.keywordColorectal cancer-
dc.subject.keywordOncologic outcome-
dc.subject.keywordtumor phenotype-
dc.subject.keywordPostoperative complication-
dc.subject.keywordPrognostic nutritional index-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameCho, Min Soo-
dc.contributor.alternativeNameHan, Jeong Hee-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorCho, Min Soo-
dc.contributor.affiliatedAuthorHan, Jeong Hee-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.citation.volume143-
dc.citation.number7-
dc.citation.startPage1235-
dc.citation.endPage1242-
dc.identifier.bibliographicCitationJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.143(7) : 1235-1242, 2017-
dc.identifier.rimsid61191-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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