Cited 39 times in
Impact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 조민수 | - |
dc.contributor.author | 한정희 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2018-07-20T08:31:56Z | - |
dc.date.available | 2018-07-20T08:31:56Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161269 | - |
dc.description.abstract | PURPOSE: The prognostic nutritional index (PNI) has been reported to be a predictive marker for surgical outcomes and prognosis in gastrointestinal malignancies. In this study, we aimed to identify the impact of preoperative PNI on the recovery and long-term oncologic outcome of patients with colorectal cancer (CRC). METHODS: A total of 3569 patients who underwent curative resection for CRC were enrolled, and their medical records were analyzed retrospectively. Preoperative PNI was calculated as 10× serum albumin concentration (g/dL) + 0.005 × total lymphocyte count (/mm3). The occurrence of postoperative complications, duration of hospital stay, disease-free survival, and overall survival were analyzed according to the preoperative PNI. In addition, PNI was compared according to the status of pathologic factors. RESULTS: The postoperative complication rate and postoperative duration of hospital stay increased significantly as PNI increased. Patients with a lower PNI showed a worse survival outcome. Increased depth of tumor invasion, presence of distant metastasis, and poorer histologic grade were associated with a lower PNI. The cut-point of preoperative PNI was calculated as 50, and patients with PNI > 50 showed a markedly better survival outcome. Furthermore, patients with PNI > 50 showed better results in postoperative complication rate and postoperative duration of hospital stay. CONCLUSION: Preoperative PNI is a simple and efficient indicator (cut-point 50) for estimating the recovery and oncologic outcome of patients. A low PNI was associated with increased occurrence of postoperative complications, prolonged hospital stay, poor oncologic outcome, and aggressive tumor phenotypes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Colorectal Neoplasms/mortality* | - |
dc.subject.MESH | Colorectal Neoplasms/pathology* | - |
dc.subject.MESH | Colorectal Neoplasms/surgery | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nutrition Assessment* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Impact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Gyoung Tae Noh | - |
dc.contributor.googleauthor | Jeonghee Han | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.identifier.doi | 10.1007/s00432-017-2366-x | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03817 | - |
dc.contributor.localId | A05065 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J01283 | - |
dc.identifier.eissn | 1432-1335 | - |
dc.identifier.pmid | 28243747 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00432-017-2366-x | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | Oncologic outcome | - |
dc.subject.keyword | tumor phenotype | - |
dc.subject.keyword | Postoperative complication | - |
dc.subject.keyword | Prognostic nutritional index | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Cho, Min Soo | - |
dc.contributor.alternativeName | Han, Jeong Hee | - |
dc.contributor.alternativeName | Hur, Hyuk | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Cho, Min Soo | - |
dc.contributor.affiliatedAuthor | Han, Jeong Hee | - |
dc.contributor.affiliatedAuthor | Hur, Hyuk | - |
dc.citation.volume | 143 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1235 | - |
dc.citation.endPage | 1242 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.143(7) : 1235-1242, 2017 | - |
dc.identifier.rimsid | 61191 | - |
dc.type.rims | ART | - |
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