0 35

Cited 0 times in

Local Injection of Hyaluronic Acid Filler Improves Open Gingival Embrasure: Validation Through a Rat Model

Authors
 Soojin Pi  ;  Yoon Jeong Choi  ;  Soonshin Hwang  ;  Dong‐Won Lee  ;  Jong In Yook  ;  Kyung‐Ho Kim  ;  Chooryung J. Chung 
Citation
 Journal of Periodontology, Vol.88(11) : 1221-1230, 2017 
Journal Title
 Journal of Periodontology 
ISSN
 0022-3492 
Issue Date
2017
Keywords
Biocompatible materials ; gingiva ; orthodontics ; research design ; tooth movement techniques
Abstract
BACKGROUND: The open gingival embrasure, the so-called black triangle, is one of the unsolved dilemmas in adult dentistry. Although various techniques have been introduced to improve black triangles, the lack of reproducible experimental models has prevented development of successful protocols to regenerate or to compensate loss of the interdental papilla. Therefore, the objective of this study is first to develop a reliable animal model of open gingival embrasure and then to validate a minimally invasive injection technique using hyaluronic acid (HA) filler to augment the interdental papilla. METHODS: To reproduce open gingival embrasure in rats, rapid space opening was induced between the mandibular incisors by attachment of a compression spring. Loss of interdental papilla height was morphologically evaluated and calculated using standardized serial photographs, microcomputed tomography, and histologic sections. Afterward, HA fillers or phosphate-buffered saline (PBS) was locally injected, and changes in the interdental papilla were evaluated. RESULTS: After 7 days of space opening, the margin of the interdental papilla between the mandibular incisors gradually became irregular and flat, indicating a condition similar to the open gingival embrasure (P <0.05). Local injection of HA filler induced an augmentation effect of the interdental papilla compared with injection of PBS (P <0.05). Interdental papilla became convex, and inner granules containing HA were detected within the submucosal layer after its injection. CONCLUSIONS: Open gingival embrasure was reproduced reliably in vivo. Local injection of HA filler was validated as a meaningful minimally invasive procedure to improve open gingival embrasure.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161259
DOI
10.1902/jop.2017.170101
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
김경호(Kim, Kyung Ho) ; 육종인(Yook, Jong In) ; 이동원(Lee, Dong Won) ; 정주령(Chung, Choo Ryung) ; 최윤정(Choi, Yoon Jeong) ; 황순신(Hwang, Soon Shin)
사서에게 알리기
  feedback
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1902/jop.2017.170101
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse