Cited 4 times in
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | Sang-Wook Lee | - |
dc.contributor.author | Geumju Park | - |
dc.contributor.author | Sung Ho Moon | - |
dc.date.accessioned | 2018-07-20T08:26:38Z | - |
dc.date.available | 2018-07-20T08:26:38Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161195 | - |
dc.description.abstract | BACKGROUND: Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is optimal. This study aimed to assess the outcome and failure patterns in tonsil cancer patients treated with either approaches. METHODS: We retrospectively reviewed medical records of 586 patients with tonsil cancer, treated between 1998 and 2010 at 16 hospitals in Korea. Two hundred and one patients received radiotherapy and chemotherapy (CRT), while 385 patients received surgery followed by radiotherapy and/or chemotherapy (SRT). Compared with the SRT group, patients receiving CRT were older, with more advanced T stage and received higher radiotherapy dose given by intensity modulation techniques. Overall survival (OS), disease-free survival (DFS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), and clinicopathologic factors were analyzed. RESULTS: At follow-up, the 5-year OS, DFS, LRRFS and DMFS rates in the CRT group were 82, 78, 89, and 94%, respectively, and in the SRT group were 81, 73, 87, and 89%, respectively. Old age, current smoking, poor performance status, advanced T stage, nodal involvement, and induction chemotherapy were associated with poor OS. Induction chemotherapy had a negative prognostic impact on OS in both treatment groups (p = 0.001 and p = 0.033 in the CRT and SRT groups, respectively). CONCLUSIONS: In our multicenter, retrospective study of tonsil cancer patients, the combined use of radiotherapy and chemotherapy resulted in comparable oncologic outcome to surgery followed by postoperative radiotherapy, despite higher-risk patients having been treated with the definitive radiotherapy. Induction chemotherapy approaches combined with either surgery or definitive radiotherapy were associated with unfavorable outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Sanghyuk Song | - |
dc.contributor.googleauthor | Hong-Gyun Wu | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Mi Sun Kim | - |
dc.contributor.googleauthor | Yong Chan Ahn | - |
dc.contributor.googleauthor | Dongryul Oh | - |
dc.contributor.googleauthor | Hyo Jung Park | - |
dc.contributor.googleauthor | Kwan Ho Cho | - |
dc.contributor.googleauthor | Yeon-Sil Kim | - |
dc.contributor.googleauthor | Yongkyun Won | - |
dc.contributor.googleauthor | Young-Taek Oh | - |
dc.contributor.googleauthor | Won-Taek Kim | - |
dc.contributor.googleauthor | Jae-Uk Jeong | - |
dc.identifier.doi | 10.1186/s12885-017-3571-3 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A03240 | - |
dc.relation.journalcode | J00351 | - |
dc.identifier.eissn | 1471-2407 | - |
dc.identifier.pmid | 28854890 | - |
dc.subject.keyword | Adjuvant radiotherapy | - |
dc.subject.keyword | Chemoradiotherapy | - |
dc.subject.keyword | Induction chemotherapy | - |
dc.subject.keyword | Surgery | - |
dc.subject.keyword | Tonsil cancer | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 598 | - |
dc.identifier.bibliographicCitation | BMC CANCER, Vol.17(1) : 598, 2017 | - |
dc.identifier.rimsid | 61120 | - |
dc.type.rims | ART | - |
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