Cited 7 times in
Pathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구교철 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2018-07-20T08:25:45Z | - |
dc.date.available | 2018-07-20T08:25:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161180 | - |
dc.description.abstract | Background: A web-based multicenter Korean Prostate Cancer Database (K-CaP) was established to provide urologists with information on Korean prostate cancer (PCa) patients treated with radical prostatectomy (RP). We utilized the K-CaP registry to identify pathological features and oncological outcomes of Korean PCa patients eligible for active surveillance (AS). Methods: The K-CaP registry consisted of 6415 patients who underwent RP from May 2001 to April 2013 at five institutions. Preoperative clinicopathological data were collected to identify patients who were eligible for at least one contemporary AS protocol. Patients who had received neoadjuvant androgen deprivation therapy or a 5α-reductase inhibitor, who had <10 total biopsy cores, or who had incomplete data were excluded. Biochemical recurrence (BCR) was defined as prostate-specific antigen (PSA) level ≥0.2 ng/ml following RP. Results: A total of 560 patients were identified, and the median follow-up period was 52.0 (interquartile range, 39.0-67.3) months. Pathologically insignificant PCa, defined as organ-confined disease with Gleason score ≤6 was observed in 314 (56.1%) patients. Pathological upgrading (Gleason score ≥7) and upstaging (≥pT3) were observed in 237 (42.3%) and 75 (13.4%) patients, respectively. Unfavorable disease (extracapsular extension, seminal vesicle invasion, or Gleason score ≥8) was observed in 85 (15.2%) patients. PSA density ≤0.2 ng/ml/cc and maximal single core involvement ≤20% were revealed as independent preoperative predictors of pathologically insignificant PCa. Conclusion: Contemporary Western AS protocols unreliably predict pathologically insignificant PCa in Korean men. Korean men may harbor more aggressive PCa features than Western men, and thus, a more stringent AS protocol is needed. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prostate-Specific Antigen/metabolism* | - |
dc.subject.MESH | Prostatectomy/methods* | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Registries | - |
dc.title | Pathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | Jae Yong Jeong | - |
dc.contributor.googleauthor | In Young Choi | - |
dc.contributor.googleauthor | Ji Youl Lee | - |
dc.contributor.googleauthor | Jun Hyuk Hong | - |
dc.contributor.googleauthor | Choung-Soo Kim | - |
dc.contributor.googleauthor | Hyun Moo Lee | - |
dc.contributor.googleauthor | Sung Kyu Hong | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.1093/jjco/hyx101 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J01207 | - |
dc.identifier.eissn | 1465-3621 | - |
dc.identifier.pmid | 28981735 | - |
dc.identifier.url | https://academic.oup.com/jjco/article/47/10/981/3979097 | - |
dc.subject.keyword | prostate cancer | - |
dc.subject.keyword | prostate-specific antigen | - |
dc.subject.keyword | surveillance | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Lee, Kwang Suk | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Suk | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.citation.volume | 47 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 981 | - |
dc.citation.endPage | 985 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Vol.47(10) : 981-985, 2017 | - |
dc.identifier.rimsid | 61105 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.