0 60

Cited 1 times in

Pathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry

DC FieldValueLanguage
dc.contributor.author구교철-
dc.contributor.author나군호-
dc.contributor.author이광석-
dc.contributor.author이승환-
dc.contributor.author정병하-
dc.date.accessioned2018-07-20T08:25:45Z-
dc.date.available2018-07-20T08:25:45Z-
dc.date.issued2017-
dc.identifier.issn0368-2811-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161180-
dc.description.abstractBackground: A web-based multicenter Korean Prostate Cancer Database (K-CaP) was established to provide urologists with information on Korean prostate cancer (PCa) patients treated with radical prostatectomy (RP). We utilized the K-CaP registry to identify pathological features and oncological outcomes of Korean PCa patients eligible for active surveillance (AS). Methods: The K-CaP registry consisted of 6415 patients who underwent RP from May 2001 to April 2013 at five institutions. Preoperative clinicopathological data were collected to identify patients who were eligible for at least one contemporary AS protocol. Patients who had received neoadjuvant androgen deprivation therapy or a 5α-reductase inhibitor, who had <10 total biopsy cores, or who had incomplete data were excluded. Biochemical recurrence (BCR) was defined as prostate-specific antigen (PSA) level ≥0.2 ng/ml following RP. Results: A total of 560 patients were identified, and the median follow-up period was 52.0 (interquartile range, 39.0-67.3) months. Pathologically insignificant PCa, defined as organ-confined disease with Gleason score ≤6 was observed in 314 (56.1%) patients. Pathological upgrading (Gleason score ≥7) and upstaging (≥pT3) were observed in 237 (42.3%) and 75 (13.4%) patients, respectively. Unfavorable disease (extracapsular extension, seminal vesicle invasion, or Gleason score ≥8) was observed in 85 (15.2%) patients. PSA density ≤0.2 ng/ml/cc and maximal single core involvement ≤20% were revealed as independent preoperative predictors of pathologically insignificant PCa. Conclusion: Contemporary Western AS protocols unreliably predict pathologically insignificant PCa in Korean men. Korean men may harbor more aggressive PCa features than Western men, and thus, a more stringent AS protocol is needed.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfJapanese Journal of Clinical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProstate-Specific Antigen/metabolism*-
dc.subject.MESHProstatectomy/methods*-
dc.subject.MESHProstatic Neoplasms/diagnosis*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHRegistries-
dc.titlePathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorKwang Suk Lee-
dc.contributor.googleauthorJae Yong Jeong-
dc.contributor.googleauthorIn Young Choi-
dc.contributor.googleauthorJi Youl Lee-
dc.contributor.googleauthorJun Hyuk Hong-
dc.contributor.googleauthorChoung-Soo Kim-
dc.contributor.googleauthorHyun Moo Lee-
dc.contributor.googleauthorSung Kyu Hong-
dc.contributor.googleauthorSeok-Soo Byun-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi10.1093/jjco/hyx101-
dc.contributor.localIdA00188-
dc.contributor.localIdA01227-
dc.contributor.localIdA02668-
dc.contributor.localIdA02938-
dc.contributor.localIdA03607-
dc.relation.journalcodeJ01207-
dc.identifier.eissn1465-3621-
dc.identifier.pmid28981735-
dc.identifier.urlhttps://academic.oup.com/jjco/article/47/10/981/3979097-
dc.subject.keywordprostate cancer-
dc.subject.keywordprostate-specific antigen-
dc.subject.keywordsurveillance-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameLee, Kwang Suk-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorLee, Kwang Suk-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.citation.volume47-
dc.citation.number10-
dc.citation.startPage981-
dc.citation.endPage985-
dc.identifier.bibliographicCitationJapanese Journal of Clinical Oncology, Vol.47(10) : 981-985, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.