0 368

Cited 54 times in

A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues

DC FieldValueLanguage
dc.contributor.author유지환-
dc.contributor.author윤주헌-
dc.contributor.author정연욱-
dc.date.accessioned2018-07-20T08:25:28Z-
dc.date.available2018-07-20T08:25:28Z-
dc.date.issued2017-
dc.identifier.issn0003-2700-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161176-
dc.description.abstractIn this study, the far-red-emitting fluorescence probe 1, containing a rhodamine derivative and a hydrazide reactive group, was developed for peroxynitrite detection and imaging. This probe, which is cell permeable and shows high sensitivity and selectivity in fluorometric detection of peroxynitrite over other ROS/RNS, was successfully utilized to detect exogenous and endogenous peroxynitrite in HeLa and RAW 264.7 cells, respectively. More importantly, 1 can also be used to detect endogenous peroxynitrite generated in Pseudomonas aeruginosa (PAO1)-infected mouse bone marrow-derived neutrophils. We anticipate that the new probe will serve as a powerful molecular imaging tool in investigations of the role(s) played by peroxynitrite in a variety of physiological and pathological contexts.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfANALYTICAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorDi Wu-
dc.contributor.googleauthorJae-Chan Ryu-
dc.contributor.googleauthorYoun Wook Chung-
dc.contributor.googleauthorDayoung Lee-
dc.contributor.googleauthorJi-Hwan Ryu-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorJuyoung Yoon-
dc.identifier.doi10.1021/acs.analchem.7b02707-
dc.contributor.localIdA04611-
dc.contributor.localIdA02604-
dc.contributor.localIdA03654-
dc.relation.journalcodeJ00136-
dc.identifier.eissn1520-6882-
dc.identifier.pmid28920425-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.analchem.7b02707-
dc.contributor.alternativeNameRyu, Ji Hwan-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameChung, Youn Wook-
dc.contributor.affiliatedAuthorRyu, Ji Hwan-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorChung, Youn Wook-
dc.citation.volume89-
dc.citation.number20-
dc.citation.startPage10924-
dc.citation.endPage10931-
dc.identifier.bibliographicCitationANALYTICAL CHEMISTRY, Vol.89(20) : 10924-10931, 2017-
dc.identifier.rimsid61101-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.