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Is suspicious upstaging on multiparametric magnetic resonance imaging useful in improving the reliability of Prostate Cancer Research International Active Surveillance (PRIAS) criteria? Use of the K-CaP registry
DC Field | Value | Language |
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dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2018-07-20T08:25:24Z | - |
dc.date.available | 2018-07-20T08:25:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1078-1439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161174 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: To evaluate the clinical effects of suspicious upstaging on multiparametric magnetic resonance imaging (mpMRI) for improving the quality of Prostate Cancer Research International Active Surveillance (PRIAS) criteria. MATERIAL AND METHODS: A total of 363 patients with low-risk prostate cancer (PCa) were selected from the K-CaP registry (the multicenter Korean PCa Database). Patients were divided into 2 groups according to the results of mpMRI (with or without suspicious upstaging). The variables for predicting significant PCa, defined as locally advanced PCa, Gleason score≥7, or tumor volume>0.5cc or all of these, and adverse PCa, defined as locally advanced PCa, Gleason score≥7 (4+3), or tumor volume>2.5cc or all of these, were assessed. RESULTS: The mpMRI led to "suspicious" upstaging in 56 patients (15.4%). Significant PCa (98.2% vs. 74.6%, P<0.001) and adverse PCa (85.7% vs. 32.6%, P<0.001) were more common in patients with suspicious upstaging. The sensitivity/specificity of mpMRI for significant PCa and adverse PCa were 25.4%/98.2% and 32.4%/96.3%, respectively. On multivariate analyses, suspicious upstaging on mpMRI (odds ratio: 15.82, P = 0.007) was a predictor for significant PCa in addition to PRIAS criteria and age at diagnosis. In addition, suspicious upstaging on mpMRI (odds ratio: 11.11, P<0.001) was a significant predictor for adverse PCa in addition to PRIAS criteria, age at diagnosis, and body mass index. CONCLUSION: Along with the PRIAS criteria, suspicious upstaging on mpMRI is a potent diagnostic tool for distinguishing patients suitable for active surveillance among patients with low-risk PCa. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prostatectomy/methods* | - |
dc.subject.MESH | Prostatic Neoplasms/epidemiology* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.title | Is suspicious upstaging on multiparametric magnetic resonance imaging useful in improving the reliability of Prostate Cancer Research International Active Surveillance (PRIAS) criteria? Use of the K-CaP registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Sangjun Yoo | - |
dc.contributor.googleauthor | Jun Hyuk Hong | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Ji Youl Lee | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Choung-Soo Kim | - |
dc.identifier.doi | 10.1016/j.urolonc.2016.07.014 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02774 | - |
dc.identifier.eissn | 1873-2496 | - |
dc.identifier.pmid | 28476529 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1078143916302009 | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Pathology | - |
dc.subject.keyword | Prostatectomy | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e7 | - |
dc.citation.endPage | e13 | - |
dc.identifier.bibliographicCitation | UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, Vol.35(7) : e7-e13, 2017 | - |
dc.identifier.rimsid | 61099 | - |
dc.type.rims | ART | - |
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