Cited 25 times in
Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2018-07-20T08:23:15Z | - |
dc.date.available | 2018-07-20T08:23:15Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161139 | - |
dc.description.abstract | Incidence, epidemiology, and risk factors of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients can vary from different cohorts and countries. Therefore, we performed a nationwide study to establish a proper antifungal prophylaxis strategies based on risk stratifications of IFDs after all-HSCT in Korea (RISK study). This was a multicenter, retrospective, and observational study in Korea. All consecutive adult patients who received allo-HSCT in 2013 were included. The 12-month cumulative incidence of proven/probable IFDs (PP-IFDs) was calculated during the early (days 0 to 40), late (days 41 to 100), and very late (days 101 to 365) phases after allo-HSCT. Cox proportional hazard regression analysis was performed to identify risk factors for PP-IFDs at each phase. A total 521 allo-HSCT cases in 518 patients were analyzed. Overall cumulative incidence of PP-IFDs were 4.09% (95% confidence interval [CI], 2.38 to 5.81), 7.38% (95% CI, 5.09 to 9.67), and 15.36% (95% CI, 12.04 to 18.68) at the early, late and very phases, respectively. In multiple Cox regression analysis, variables were associated with PP-IFDs in each period were identified. Variables associated with early phase include underlying pulmonary diseases, underlying nonmalignant stable or chronic disease at allo-HSCT, unrelated or family mismatched donor, and prolonged neutropenia. Variables associated with the late phase include high ferritin level at the time point of allo-HSCT, use of secondary immunosuppressive agents due to refractory graft-versus-host disease (GVHD), and cytomegalovirus reactivation. For the very late phase, variables were secondary neutropenia, severe chronic GVHD, and use of TNF-alpha inhibitor for refractory GVHD. This study revealed the high cumulative incidence of IFDs in Korean allo-HSCT recipients, which have distinct risk factors in each phase after allo-HSCT. Our findings indicate that tailored antifungal prophylaxis is necessary for high-risk patients. Clinicians should consider using mold-active antifungal prophylaxis in allo-HSCT recipients who have high risks at different treatment period. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Carden Jennings Publishing | - |
dc.relation.isPartOf | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Epidemiology and Risk Factors for Invasive Fungal Diseases among Allogeneic Hematopoietic Stem Cell Transplant Recipients in Korea: Results of "RISK" Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jae-Ki Choi | - |
dc.contributor.googleauthor | Sung-Yeon Cho | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Joon-Ho Moon | - |
dc.contributor.googleauthor | Sung-Han Kim | - |
dc.contributor.googleauthor | Je-Hwan Lee | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Jun-Ho Jang | - |
dc.contributor.googleauthor | Bo-Jeong Seo | - |
dc.contributor.googleauthor | Young-Joo Kim | - |
dc.contributor.googleauthor | Hye-Jung Lee | - |
dc.contributor.googleauthor | Juneyoung Lee | - |
dc.contributor.googleauthor | Jong Wook Lee | - |
dc.contributor.googleauthor | Dong-Gun Lee | - |
dc.identifier.doi | 10.1016/j.bbmt.2017.06.012 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J00308 | - |
dc.identifier.eissn | 1523-6536 | - |
dc.identifier.pmid | 28668492 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1083879117305219 | - |
dc.subject.keyword | Epidemiology | - |
dc.subject.keyword | Hematopoietic stem cell transplantation | - |
dc.subject.keyword | Mycoses | - |
dc.subject.keyword | Republic of Korea | - |
dc.subject.keyword | Risk factors | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.citation.volume | 23 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1773 | - |
dc.citation.endPage | 1779 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.23(10) : 1773-1779, 2017 | - |
dc.identifier.rimsid | 61065 | - |
dc.type.rims | ART | - |
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