Cited 5 times in
Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience
DC Field | Value | Language |
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dc.contributor.author | 민유홍 | - |
dc.contributor.author | 장지은 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2018-07-20T08:23:12Z | - |
dc.date.available | 2018-07-20T08:23:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161138 | - |
dc.description.abstract | Little is known about the characteristics that make patients with acute leukemia suitable for undergoing salvage therapy by allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we analyzed the clinical outcomes of 223 patients with acute leukemia who underwent allo-HSCT while not in complete remission (CR). The primary end points were overall survival (OS) and CR rate. CR was achieved in 79.8% of patients after allo-HSCT. Acute graft-versus-host disease (GVHD) was significantly associated with CR (P = 0.045). During a median follow-up of 30.1 months, the median OS was 6.1 months. OS was significantly longer in patients with good or standard risk cytogenetic characteristics than in those with poor risk cytogenetic characteristics (P = 0.029, P = 0.030, respectively). Patients who received allo-HSCT from a matched sibling donor had better survival than those with unrelated donors (P = 0.015). Primary chemorefractoriness was not associated with poor survival (P = 0.071). The number of chemotherapies before allo-HSCT was significantly correlated with outcome (P = 0.006). Chronic GVHD was a strong predictor of a longer OS (P = 0.025). In conclusion, survival of patients with primary chemorefractory acute leukemia is not lower when treated upfront with allo-HSCT. Hence, allo-HSCT should be actively considered in such patients. Acute and chronic GVHD is associated with better outcomes patients with acute leukemia who have undergone allo-HSCT and not achieved CR. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft vs Host Disease/diagnosis* | - |
dc.subject.MESH | Graft vs Host Disease/mortality | - |
dc.subject.MESH | Graft vs Host Disease/therapy* | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation/mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukemia/diagnosis* | - |
dc.subject.MESH | Leukemia/mortality | - |
dc.subject.MESH | Leukemia/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Salvage Therapy/methods* | - |
dc.subject.MESH | Salvage Therapy/mortality | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Shin Hye Yoo | - |
dc.contributor.googleauthor | Youngil Koh | - |
dc.contributor.googleauthor | Dae-Young Kim | - |
dc.contributor.googleauthor | Jung-Hee Lee | - |
dc.contributor.googleauthor | Je-Hwan Lee | - |
dc.contributor.googleauthor | Kyoo-Hyung Lee | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Seonyang Park | - |
dc.contributor.googleauthor | Sung-Kyu Park | - |
dc.contributor.googleauthor | Dae-Sik Hong | - |
dc.contributor.googleauthor | Hyeon Gyu Yi | - |
dc.contributor.googleauthor | Chul-Soo Kim | - |
dc.contributor.googleauthor | Ji Eun Jang | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Joonho Moon | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Sang Kyun Sohn | - |
dc.contributor.googleauthor | Inho Kim | - |
dc.identifier.doi | 10.1007/s00277-017-2919-8 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A03477 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J00161 | - |
dc.identifier.eissn | 1432-0584 | - |
dc.identifier.pmid | 28091736 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00277-017-2919-8 | - |
dc.subject.keyword | Acute leukemia | - |
dc.subject.keyword | Allogeneic hematopoietic stem cell transplantation | - |
dc.subject.keyword | Chemorefractoriness | - |
dc.subject.keyword | Graft-versus-host disease | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Jang, Ji Eun | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Jang, Ji Eun | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.citation.volume | 96 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 605 | - |
dc.citation.endPage | 615 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, Vol.96(4) : 605-615, 2017 | - |
dc.identifier.rimsid | 61064 | - |
dc.type.rims | ART | - |
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