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Birmingham vasculitis activity score of more than 9.5 at diagnosis is an independent predictor of refractory disease in granulomatosis with polyangiitis

DC Field Value Language
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author유주영-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2018-07-20T08:21:53Z-
dc.date.available2018-07-20T08:21:53Z-
dc.date.issued2017-
dc.identifier.issn1756-1841-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161124-
dc.description.abstractAIM: We investigated whether clinical manifestations, anti-neutrophil cytoplasmic antibodies (ANCAs), Birmingham vasculitis activity score (BVAS) for granulomatosis with polyangiitis (GPA) and five factor score (FFS) at diagnosis can predict relapse or refractory disease in 30 histology-proven GPA patients with follow-up duration ≥ 12 weeks. METHODS: We reviewed the medical records of 30 GPA patients. We collected clinical data, ANCAs, BVAS for GPA, FFSs at diagnosis, and we compared variables between the two groups based on relapse or refractory disease. The optimal cut-offs were extrapolated. Multivariate logistic regression and Cox hazard model analyses were conducted to identify predictors of refractory disease. RESULTS: The mean age and follow-up duration of patients were 63.3 years old and 45.2 months. The mean initial BVAS for GPA, FFS (1996) and FFS (2009) were 5.4, 0.6 and 1.0. There were no significant predictors of relapse. The mean BVAS for GPA, FFS (1996) and FFS (2009) of patients with refractory disease were higher than those without (P < 0.05 for all). Patients having BVAS for GPA ≥ 9.5, FFS (1996) ≥ 2 and FFS (2009) ≥ 2 exhibited significantly enhanced risk of refractory disease than those without (relative risk 23.0, 11.0, and 55.0, respectively), and low cumulative refractory disease-free survival rates. Multivariate Cox hazard model analysis proved BVAS for GPA ≥ 9.5 was an independent predictor of refractory disease during the follow-up duration (odds ratio 12.892). CONCLUSION: BVAS for GPA ≥ 9.5 was an independent predictor of refractory disease during follow-up duration ≥ 12 weeks.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley on behalf of the Asia Pacific League of Associations for Rheumatology-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Antineutrophil Cytoplasmic/blood*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiopsy-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHDecision Support Techniques*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHDrug Resistance-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHGranulomatosis with Polyangiitis/blood-
dc.subject.MESHGranulomatosis with Polyangiitis/diagnosis*-
dc.subject.MESHGranulomatosis with Polyangiitis/drug therapy*-
dc.subject.MESHGranulomatosis with Polyangiitis/immunology-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive-
dc.subject.MESHAgents/therapeutic use*-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMedical Records-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRecurrence-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleBirmingham vasculitis activity score of more than 9.5 at diagnosis is an independent predictor of refractory disease in granulomatosis with polyangiitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJuyoung Yoo-
dc.contributor.googleauthorHo Jae Kim-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong‐Beom Park-
dc.contributor.googleauthorSang‐Won Lee-
dc.identifier.doi10.1111/1756-185X.13144-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA05157-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ01158-
dc.identifier.eissn1756-185X-
dc.identifier.pmid28766857-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13144-
dc.subject.keywordFFS-
dc.subject.keywordBVAS for GPA-
dc.subject.keywordgranulomatosis with polyangiitis-
dc.subject.keywordpredictors-
dc.subject.keywordrefractory disease-
dc.subject.keywordrelapse-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameYoo, Juyoung-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameJung, SeungMin-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorYoo, Juyoung-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorJung, SeungMin-
dc.citation.volume20-
dc.citation.number10-
dc.citation.startPage1593-
dc.citation.endPage1605-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.20(10) : 1593-1605, 2017-
dc.identifier.rimsid61013-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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