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Cited 6 times in

Factors associated with pulmonary toxicity after myeloablative conditioning using fractionated total body irradiation

DC Field Value Language
dc.contributor.author김수정-
dc.contributor.author김진석-
dc.contributor.author김현주-
dc.contributor.author민유홍-
dc.contributor.author변화경-
dc.contributor.author서창옥-
dc.contributor.author유철주-
dc.contributor.author윤홍인-
dc.contributor.author이원희-
dc.contributor.author정준원-
dc.contributor.author조재호-
dc.contributor.author양지훈-
dc.date.accessioned2018-07-20T08:18:30Z-
dc.date.available2018-07-20T08:18:30Z-
dc.date.issued2017-
dc.identifier.issn2234-1900-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161078-
dc.description.abstractPURPOSE: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. MATERIALS AND METHODS: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed. Most patients (91%) received 12 Gy in 1.5 Gy fractions twice a day. Pulmonary toxicities were diagnosed based on either radiographic evidence or reduced pulmonary function, and were subdivided into IP and IPS based on the presence or absence of concurrent infection. RESULTS: Pulmonary toxicities developed in 36 patients (62%); 16 (28%) had IP and 20 (34%) had IPS. IP was significantly associated with increased treatment-related mortality (p = 0.028) and decreased survival (p = 0.039). Multivariate analysis revealed that the risk of developing IPS was significantly higher in patients who received stem cells from a matched unrelated donor than from a matched sibling donor (p = 0.021; hazard ratio [HR] = 12.67; 95% confidence interval [CI], 1.46-110.30). Combining other conditioning agents with cyclophosphamide produced a higher tendency to develop IP (p = 0.064; HR = 6.19; 95% CI, 0.90-42.56). CONCLUSION: IP and IPS involve different risk factors and distinct pathogeneses that should be considered when planning treatments before and after TBI.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Therapeutic Radiology and Oncology-
dc.relation.isPartOfRADIATION ONCOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFactors associated with pulmonary toxicity after myeloablative conditioning using fractionated total body irradiation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHwa Kyung Byun-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorJaeho Cho-
dc.contributor.googleauthorHyun Ju Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorHyo Sun Kim-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorAndrew Jihoon Yang-
dc.contributor.googleauthorByung Min Lee-
dc.contributor.googleauthorWon Hee Lee-
dc.contributor.googleauthorJoongyo Lee-
dc.contributor.googleauthorKi Jung Ahn-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.3857/roj.2017.00290-
dc.contributor.localIdA00633-
dc.contributor.localIdA01017-
dc.contributor.localIdA04551-
dc.contributor.localIdA01407-
dc.contributor.localIdA05136-
dc.contributor.localIdA01919-
dc.contributor.localIdA02524-
dc.contributor.localIdA04777-
dc.contributor.localIdA05379-
dc.contributor.localIdA03729-
dc.contributor.localIdA03901-
dc.relation.journalcodeJ02592-
dc.identifier.eissn2234-3164-
dc.identifier.pmid29037020-
dc.subject.keywordIdiopathic pneumonia syndrome-
dc.subject.keywordInfectious pneumonia-
dc.subject.keywordStem cell transplantation-
dc.subject.keywordTotal body irradiation-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameKim, Hyun Ju-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameByun, Hwa Kyung-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.alternativeNameLee, Won Hee-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorKim, Hyun Ju-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorByun, Hwa Kyung-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorYoon, Hong In-
dc.contributor.affiliatedAuthorLee, Won Hee-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.citation.volume35-
dc.citation.number3-
dc.citation.startPage257-
dc.citation.endPage267-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY JOURNAL, Vol.35(3) : 257-267, 2017-
dc.identifier.rimsid60968-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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