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Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database

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dc.contributor.author정준-
dc.date.accessioned2018-07-20T08:18:16Z-
dc.date.available2018-07-20T08:18:16Z-
dc.date.issued2017-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161071-
dc.description.abstractPURPOSE: This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors. MATERIALS AND METHODS: The data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period; the high EL group (≥ 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups. RESULTS: A high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626; 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged ≤ 50 years (hazard ratio, 0.941; 95% CI, 0.865 to 1.024). The EL was a significant independent factor in the subgroup aged > 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer. CONCLUSION: The EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged ≤ 50 years. Favorable clinicopathologic features and active treatments can explain the main causality of the superior prognosis in the high EL group.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEducation Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorKi-Tae Hwang-
dc.contributor.googleauthorWoochul Noh-
dc.contributor.googleauthorSe-Heon Cho-
dc.contributor.googleauthorJonghan Yu-
dc.contributor.googleauthorMin Ho Park-
dc.contributor.googleauthorJoon Jeong-
dc.contributor.googleauthorHyouk Jin Lee-
dc.contributor.googleauthorJongjin Kim-
dc.contributor.googleauthorSohee Oh-
dc.contributor.googleauthorYoung A Kim-
dc.contributor.googleauthorKorean Breast Cancer Society-
dc.identifier.doi10.4143/crt.2016.528-
dc.contributor.localIdA03727-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid28161933-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordEducation-
dc.subject.keywordEducational status-
dc.subject.keywordPrognosis-
dc.subject.keywordSurvival analysis-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.affiliatedAuthorJeong, Joon-
dc.citation.volume49-
dc.citation.number4-
dc.citation.startPage1114-
dc.citation.endPage1126-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.49(4) : 1114-1126, 2017-
dc.identifier.rimsid60961-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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