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Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database
DC Field | Value | Language |
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dc.contributor.author | 정준 | - |
dc.date.accessioned | 2018-07-20T08:18:16Z | - |
dc.date.available | 2018-07-20T08:18:16Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161071 | - |
dc.description.abstract | PURPOSE: This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors. MATERIALS AND METHODS: The data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period; the high EL group (≥ 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups. RESULTS: A high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626; 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged ≤ 50 years (hazard ratio, 0.941; 95% CI, 0.865 to 1.024). The EL was a significant independent factor in the subgroup aged > 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer. CONCLUSION: The EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged ≤ 50 years. Favorable clinicopathologic features and active treatments can explain the main causality of the superior prognosis in the high EL group. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Ki-Tae Hwang | - |
dc.contributor.googleauthor | Woochul Noh | - |
dc.contributor.googleauthor | Se-Heon Cho | - |
dc.contributor.googleauthor | Jonghan Yu | - |
dc.contributor.googleauthor | Min Ho Park | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Hyouk Jin Lee | - |
dc.contributor.googleauthor | Jongjin Kim | - |
dc.contributor.googleauthor | Sohee Oh | - |
dc.contributor.googleauthor | Young A Kim | - |
dc.contributor.googleauthor | Korean Breast Cancer Society | - |
dc.identifier.doi | 10.4143/crt.2016.528 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28161933 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Education | - |
dc.subject.keyword | Educational status | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Survival analysis | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1114 | - |
dc.citation.endPage | 1126 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.49(4) : 1114-1126, 2017 | - |
dc.identifier.rimsid | 60961 | - |
dc.type.rims | ART | - |
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