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Volumetric parameters on FDG PET can predict early intrahepatic recurrence-free survival in patients with hepatocellular carcinoma after curative surgical resection

DC FieldValueLanguage
dc.contributor.author김동우-
dc.contributor.author김현정-
dc.contributor.author윤미진-
dc.contributor.author조응혁-
dc.date.accessioned2018-07-20T08:18:12Z-
dc.date.available2018-07-20T08:18:12Z-
dc.date.issued2017-
dc.identifier.issn1619-7070-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161070-
dc.description.abstractPURPOSE: This study assessed the prognostic values of volumetric parameters on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting early intrahepatic recurrence-free survival (RFS) after curative resection in patients with hepatocellular carcinoma (HCC). METHODS: A retrospective analysis was performed on 242 patients with HCC who underwent staging FDG PET and subsequent curative surgical resection. The tumor-to-non-tumorous liver uptake ratio, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the HCC lesions on PET were measured. The prognostic values of clinical factors and PET parameters for predicting overall RFS, overall survival (OS), extrahepatic RFS, and early and late intrahepatic RFS were assessed. RESULTS: The median follow-up period was 54.7 months, during which 110 patients (45.5%) experienced HCC recurrence and 62 (25.6%) died. Patients with extrahepatic and early intrahepatic recurrence showed worse OS than did those with no recurrence or late intrahepatic recurrence (p < 0.001). Serum bilirubin level, MTV, and TLG were independent prognostic factors for overall RFS and OS (p < 0.05). Only MTV and TLG were prognostic for extrahepatic RFS (p < 0.05). Serum alpha-fetoprotein and bilirubin levels, MTV, and TLG were prognostic for early intrahepatic RFS (p < 0.05) and hepatitis C virus (HCV) positivity and serum albumin level were independently prognostic for late intrahepatic RFS (p < 0.05). CONCLUSION: Intrahepatic recurrence showed different prognoses according to the time interval of recurrence in which early recurrence had as poor survival as extrahepatic recurrence. MTV and TLG on initial staging PET were significant independent factors for predicting early intrahepatic and extrahepatic RFS in patients with HCC after curative resection. Only HCV positivity and serum albumin level were significant for late intrahepatic RFS, which is mainly attributable to the de novo formation of new primary HCC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag Berlin-
dc.relation.isPartOfEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging*-
dc.subject.MESHCarcinoma, Hepatocellular/surgery*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/diagnostic imaging*-
dc.subject.MESHLiver Neoplasms/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPositron-Emission Tomography*-
dc.subject.MESHRetrospective Studies-
dc.titleVolumetric parameters on FDG PET can predict early intrahepatic recurrence-free survival in patients with hepatocellular carcinoma after curative surgical resection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Nuclear Medicine-
dc.contributor.googleauthorJeong Won Lee-
dc.contributor.googleauthorSang Hyun Hwang-
dc.contributor.googleauthorHyun Jeong Kim-
dc.contributor.googleauthorDongwoo Kim-
dc.contributor.googleauthorArthur Cho-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.1007/s00259-017-3764-7-
dc.contributor.localIdA05304-
dc.contributor.localIdA01129-
dc.contributor.localIdA02550-
dc.contributor.localIdA03887-
dc.relation.journalcodeJ00833-
dc.identifier.eissn1619-7089-
dc.identifier.pmid28695236-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00259-017-3764-7-
dc.subject.keywordFDG PET-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMetabolic tumor volume-
dc.subject.keywordPrognosis-
dc.subject.keywordRecurrence-
dc.contributor.alternativeNameKim, Dongwoo-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameCho, Arthur Eung Hyuck-
dc.contributor.affiliatedAuthorKim, Dongwoo-
dc.contributor.affiliatedAuthorKim, Hyun Jeong-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorCho, Arthur Eung Hyuck-
dc.citation.volume44-
dc.citation.number12-
dc.citation.startPage1984-
dc.citation.endPage1994-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.44(12) : 1984-1994, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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