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Effect of Polyglycolic Acid Mesh for Prevention of Pancreatic Fistula Following Distal Pancreatectomy: A Randomized Clinical Trial

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author김재근-
dc.contributor.author박준성-
dc.contributor.author윤동섭-
dc.contributor.author이우정-
dc.contributor.author황호경-
dc.date.accessioned2018-07-20T08:16:53Z-
dc.date.available2018-07-20T08:16:53Z-
dc.date.issued2017-
dc.identifier.issn2168-6254-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161040-
dc.description.abstractImportance: The rate of postoperative pancreatic fistula (POPF) after distal pancreatectomy ranges from 13% to 64%. To prevent POPF, polyglycolic acid (PGA) mesh was introduced, but its effect has been evaluated only in small numbers of patients and retrospective studies. Objective: To evaluate the efficacy of PGA mesh in preventing POPF after distal pancreatectomy. Design, Setting, and Participants: Prospective randomized clinical, single-blind (participant), parallel-group trial at 5 centers between November 2011 and April 2014. The pancreatic parenchyma was divided using a stapling device; no patient was given prophylactic octreotide. Perioperative and clinical outcomes were compared including POPF, which was graded according to the criteria of the International Study Group For Pancreatic Fistulas. A total of 97 patients aged 20 to 85 years with curable benign, premalignant, or malignant disease of the pancreatic body or tail were enrolled (44 in the PGA group and 53 in the control group). Interventions: Patients in the PGA group underwent transection of the pancreas and application of fibrin glue followed by wrapping the PGA mesh around the remnant pancreatic stump. Main Outcomes and Measures: The primary end point of this study was the development of a clinically relevant POPF (grade B or C by the International Study Group grading system). The secondary end point was the evaluation of risk factors for POPF. Results: The study therefore evaluated a total of 97 patients, 44 in the PGA group and 53 in the control group. Thirty-nine patients were women and 58 patients were men. There were no differences in mean (SD) age (59.9 [12.0] years vs 54.5 [14.1] years, P = .05), male to female ratio (1.0:1.3 vs 1.0:1.7, P = .59), malignancy (40.9% vs 32.1%, P = .37), mean (SD) pancreatic duct diameter (1.92 [0.75] mm vs 1.94 [0.95] mm, P = .47), soft pancreatic texture (90.9% vs 83.0%, P = .17), and mean (SD) thickness of the transection margin (16.9 [5.4] mm vs 16.4 [4.9] mm, P = .63) between the PGA and control groups. The rate of clinically relevant POPF (grade B or C) was significantly lower in the PGA group than in the control group (11.4% vs 28.3%, P = .04). Conclusions and Relevance: Wrapping of the cut surface of the pancreas with PGA mesh is associated with a significantly reduced rate of clinically relevant POPF. Trial Registration: clinicaltrials.gov Identifier: NCT01550406.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Medical Association-
dc.relation.isPartOfJAMA Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Pancreatic Ductal/surgery*-
dc.subject.MESHCystadenoma/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreatectomy/adverse effects*-
dc.subject.MESHPancreatectomy/methods-
dc.subject.MESHPancreatic Fistula/etiology-
dc.subject.MESHPancreatic Fistula/prevention & control*-
dc.subject.MESHPancreatic Neoplasms/surgery*-
dc.subject.MESHPolyglycolic Acid/therapeutic use*-
dc.subject.MESHPrecancerous Conditions/surgery*-
dc.subject.MESHProspective Studies-
dc.subject.MESHSingle-Blind Method-
dc.subject.MESHSurgical Mesh*-
dc.subject.MESHYoung Adult-
dc.titleEffect of Polyglycolic Acid Mesh for Prevention of Pancreatic Fistula Following Distal Pancreatectomy: A Randomized Clinical Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJin-Young Jang-
dc.contributor.googleauthorYong Chan Shin-
dc.contributor.googleauthorYoungmin Han-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorHo-Seong Han-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorDong Sup Yoon-
dc.contributor.googleauthorJae Keun Kim-
dc.contributor.googleauthorYoo Seok Yoon-
dc.contributor.googleauthorDae Wook Hwang-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorJin Seok Heo-
dc.contributor.googleauthorMee Joo Kang-
dc.contributor.googleauthorYe Rim Chang-
dc.contributor.googleauthorJihoon Chang-
dc.contributor.googleauthorWoohyun Jung-
dc.contributor.googleauthorSun-Whe Kim-
dc.identifier.doi10.1001/jamasurg.2016.3644-
dc.contributor.localIdA00088-
dc.contributor.localIdA00857-
dc.contributor.localIdA01672-
dc.contributor.localIdA02548-
dc.contributor.localIdA02993-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ01203-
dc.identifier.eissn2168-6262-
dc.identifier.pmid27784046-
dc.identifier.urlhttps://jamanetwork.com/journals/jamasurgery/fullarticle/2572733-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Jae Keun-
dc.contributor.alternativeNamePark, Joon Seong-
dc.contributor.alternativeNameYoon, Dong Sup-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameHwang, Ho Kyoung-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Jae Keun-
dc.contributor.affiliatedAuthorPark, Joon Seong-
dc.contributor.affiliatedAuthorYoon, Dong Sup-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorHwang, Ho Kyoung-
dc.citation.volume152-
dc.citation.number2-
dc.citation.startPage150-
dc.citation.endPage155-
dc.identifier.bibliographicCitationJAMA Surgery, Vol.152(2) : 150-155, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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