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Cited 17 times in

Increasing Resistance to Extended-Spectrum Cephalosporins, Fluoroquinolone, and Carbapenem in Gram-Negative Bacilli and the Emergence of Carbapenem Non-Susceptibility in Klebsiella pneumoniae: Analysis of Korean Antimicrobial Resistance Monitoring System (KARMS) Data From 2013 to 2015

DC FieldValueLanguage
dc.contributor.author김도균-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author이혁민-
dc.contributor.author정석훈-
dc.date.accessioned2018-07-20T08:16:44Z-
dc.date.available2018-07-20T08:16:44Z-
dc.date.issued2017-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161038-
dc.description.abstractBACKGROUND: National surveillance of antimicrobial resistance becomes more important for the control of antimicrobial resistance and determination of treatment guidelines. We analyzed Korean Antimicrobial Resistance Monitoring System (KARMS) data collected from 2013 to 2015. METHODS: Of the KARMS participants, 16 secondary or tertiary hospitals consecutively reported antimicrobial resistance rates from 2013 to 2015. Data from duplicate isolates and institutions with fewer than 20 isolates were excluded. To determine the long-term trends, previous KARMS data from 2004 to 2012 were also considered. RESULTS: The prevalence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium from 2013 to 2015 was 66-72% and 29-31%, respectively. The resistance rates of Escherichia coli to cefotaxime and cefepime gradually increased to 35% and 31%, respectively, and fluoroquinolone resistance reached 48% in 2015. The resistance rates of Klebsiella pneumoniae to cefotaxime, cefepime, and carbapenem were 38-41%, 33-41%, and <0.1-2%, respectively, from 2013 to 2015. The carbapenem susceptibility rates of E. coli and K. pneumoniae decreased from 100% and 99.3% in 2011 to 99.0% and 97.0% in 2015, respectively. The resistance rate of Pseudomonas aeruginosa to carbapenem increased to 35% and the prevalence of carbapenem-resistant Acinetobacter baumannii increased from 77% in 2013 to 85% in 2015. CONCLUSIONS: Between 2013 and 2015, the resistance rates of E. coli to third- and fourth-generation cephalosporins increased continuously, while carbapenem-susceptibility gradually decreased, particularly in K. pneumoniae. The prevalence of carbapenem-resistant P. aeruginosa and A. baumannii increased significantly; therefore, few treatment options remain for these resistant strains.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfAnnals of Laboratory Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHCarbapenems/pharmacology-
dc.subject.MESHCephalosporins/pharmacology-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHDrug Resistance, Bacterial*-
dc.subject.MESHFluoroquinolones/pharmacology-
dc.subject.MESHGram-Negative Bacteria/drug effects*-
dc.subject.MESHGram-Negative Bacteria/isolation & purification-
dc.subject.MESHGram-Positive Bacteria/drug effects-
dc.subject.MESHGram-Positive Bacteria/isolation & purification-
dc.subject.MESHHumans-
dc.subject.MESHKlebsiella pneumoniae/drug effects*-
dc.subject.MESHKlebsiella pneumoniae/isolation & purification-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSecondary Care Centers-
dc.subject.MESHTertiary Care Centers-
dc.titleIncreasing Resistance to Extended-Spectrum Cephalosporins, Fluoroquinolone, and Carbapenem in Gram-Negative Bacilli and the Emergence of Carbapenem Non-Susceptibility in Klebsiella pneumoniae: Analysis of Korean Antimicrobial Resistance Monitoring System (KARMS) Data From 2013 to 2015-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorDokyun Kim-
dc.contributor.googleauthorJi Young Ahn-
dc.contributor.googleauthorChae Hoon Lee-
dc.contributor.googleauthorSook Jin Jang-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.3343/alm.2017.37.3.231-
dc.contributor.localIdA04891-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03286-
dc.contributor.localIdA03619-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid28224769-
dc.subject.keywordAcinetobacter baumannii-
dc.subject.keywordAntimicrobial drug resistance-
dc.subject.keywordKARMS-
dc.subject.keywordSurveillance-
dc.contributor.alternativeNameKim, Dokyun-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Hyuk Min-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorKim, Dokyun-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Hyuk Min-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.citation.volume37-
dc.citation.number3-
dc.citation.startPage231-
dc.citation.endPage239-
dc.identifier.bibliographicCitationAnnals of Laboratory Medicine, Vol.37(3) : 231-239, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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