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Outbreak of KPC-2-producing Enterobacteriaceae caused by clonal dissemination of Klebsiella pneumoniae ST307 carrying an IncX3-type plasmid harboring a truncated Tn4401a

DC FieldValueLanguage
dc.contributor.author이경원-
dc.contributor.author이혁민-
dc.contributor.author정석훈-
dc.date.accessioned2018-07-20T08:16:41Z-
dc.date.available2018-07-20T08:16:41Z-
dc.date.issued2017-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161037-
dc.description.abstractOver a 5-month period between the end of June and the beginning of November in 2015, a KPC-producing Enterobacteriaceae outbreak occurred in a general hospital in Busan, South Korea, being associated with a total of 50 clinical isolates from 47 patients. Multilocus sequence typing and pulsed-field gel electrophoresis were carried out for strain typing and whole-genome sequencing was performed to characterize the plasmids. A clonal spread of K. pneumoniae sequence type 307 (ST307) carrying a self-transferable IncX3-type plasmid harboring blaKPC-2 was responsible for the outbreak. Sporadic emergence of K. pneumoniae ST697 carrying an IncFII-type plasmid and a ST11 isolate harboring a small plasmid devoid of any known origin of replication were observed to be associated with blaKPC-3, but no further dissemination of these strains was identified. The results indicated a healthcare-associated infection associated with a blaKPC-harboring plasmid dissemination and a clonal spread of KPC-producing Enterobacteriaceae.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Biomedical-
dc.relation.isPartOfDiagnostic Microbiology and Infectious Disease-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHCross Infection/microbiology-
dc.subject.MESHDisease Outbreaks-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field/methods-
dc.subject.MESHEnterobacteriaceae/genetics-
dc.subject.MESHEnterobacteriaceae/isolation & purification*-
dc.subject.MESHEnterobacteriaceae Infections/microbiology-
dc.subject.MESHHumans-
dc.subject.MESHKlebsiella Infections/microbiology*-
dc.subject.MESHKlebsiella pneumoniae/genetics-
dc.subject.MESHKlebsiella pneumoniae/isolation & purification*-
dc.subject.MESHMicrobial Sensitivity Tests/methods-
dc.subject.MESHMolecular Epidemiology/methods-
dc.subject.MESHMultilocus Sequence Typing/methods-
dc.subject.MESHPlasmids/genetics*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSequence Analysis, DNA/methods-
dc.subject.MESHbeta-Lactamases/genetics*-
dc.titleOutbreak of KPC-2-producing Enterobacteriaceae caused by clonal dissemination of Klebsiella pneumoniae ST307 carrying an IncX3-type plasmid harboring a truncated Tn4401a-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorJung Ok Kim-
dc.contributor.googleauthorSae Am Song-
dc.contributor.googleauthorEun-Jeong Yoon-
dc.contributor.googleauthorJeong Hwan Shin-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.1016/j.diagmicrobio.2016.12.012-
dc.contributor.localIdA02649-
dc.contributor.localIdA03286-
dc.contributor.localIdA03619-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid28185686-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0732889316304308-
dc.subject.keywordCarbapenem resistance-
dc.subject.keywordIncX3-
dc.subject.keywordKlebsiella pneumoniae-
dc.subject.keywordST307-
dc.subject.keywordTn4401a-
dc.subject.keywordbla(KPC)-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Hyuk Min-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Hyuk Min-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.citation.volume87-
dc.citation.number4-
dc.citation.startPage343-
dc.citation.endPage348-
dc.identifier.bibliographicCitationDiagnostic Microbiology and Infectious Disease, Vol.87(4) : 343-348, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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