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Outbreak of KPC-2-producing Enterobacteriaceae caused by clonal dissemination of Klebsiella pneumoniae ST307 carrying an IncX3-type plasmid harboring a truncated Tn4401a

Authors
 Jung Ok Kim  ;  Sae Am Song  ;  Eun-Jeong Yoon  ;  Jeong Hwan Shin  ;  Hyukmin Lee  ;  Seok Hoon Jeong  ;  Kyungwon Lee 
Citation
 Diagnostic Microbiology and Infectious Disease, Vol.87(4) : 343-348, 2017 
Journal Title
 Diagnostic Microbiology and Infectious Disease 
ISSN
 0732-8893 
Issue Date
2017
MeSH
Bacterial Proteins/genetics ; Cross Infection/microbiology ; Disease Outbreaks ; Electrophoresis, Gel, Pulsed-Field/methods ; Enterobacteriaceae/genetics ; Enterobacteriaceae/isolation & purification* ; Enterobacteriaceae Infections/microbiology ; Humans ; Klebsiella Infections/microbiology* ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification* ; Microbial Sensitivity Tests/methods ; Molecular Epidemiology/methods ; Multilocus Sequence Typing/methods ; Plasmids/genetics* ; Republic of Korea ; Sequence Analysis, DNA/methods ; beta-Lactamases/genetics*
Keywords
Carbapenem resistance ; IncX3 ; Klebsiella pneumoniae ; ST307 ; Tn4401a ; bla(KPC)
Abstract
Over a 5-month period between the end of June and the beginning of November in 2015, a KPC-producing Enterobacteriaceae outbreak occurred in a general hospital in Busan, South Korea, being associated with a total of 50 clinical isolates from 47 patients. Multilocus sequence typing and pulsed-field gel electrophoresis were carried out for strain typing and whole-genome sequencing was performed to characterize the plasmids. A clonal spread of K. pneumoniae sequence type 307 (ST307) carrying a self-transferable IncX3-type plasmid harboring blaKPC-2 was responsible for the outbreak. Sporadic emergence of K. pneumoniae ST697 carrying an IncFII-type plasmid and a ST11 isolate harboring a small plasmid devoid of any known origin of replication were observed to be associated with blaKPC-3, but no further dissemination of these strains was identified. The results indicated a healthcare-associated infection associated with a blaKPC-harboring plasmid dissemination and a clonal spread of KPC-producing Enterobacteriaceae.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161037
DOI
10.1016/j.diagmicrobio.2016.12.012
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
이경원(Lee, Kyungwon)
이혁민(Lee, Hyuk Min)
정석훈(Jeong, Seok Hoon)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0732889316304308
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