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Insulin resistance and bone age advancement in girls with central precocious puberty

Authors
 Jin Ho Hur  ;  Sora Park  ;  Mo Kyung Jung  ;  Seok Jin Kang  ;  Ahreum Kwon  ;  Hyun Wook Chae  ;  Ho-Seong Kim  ;  Duk Hee Kim 
Citation
 Annals of Pediatric Endocrinology & Metabolism, Vol.22(3) : 176-182, 2017 
Journal Title
 Annals of Pediatric Endocrinology & Metabolism 
ISSN
 2287-1012 
Issue Date
2017
Keywords
Gonadotropin-releasing hormone ; Luteinizing hormone ; Precocious puberty
Abstract
PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. METHODS: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed. Insulin resistance parameters were calculated using the homeostasis model assessment-insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) models. RESULTS: BA, BA advancement, free estradiol index, insulin, and HOMA-IR increased significantly in girls with high body mass index (BMI) compared with that of girls with low BMI in cases of CPP. HOMA-IR was positively correlated with BA advancement and BMI but negatively correlated with SHBG. QUICKI was negatively correlated with BA advancement and BMI and positively correlated with SHBG. When HOMA-IR increased by 1, the odds for BA advancement increased 120% after adjusting for age and BMI (P=0.033). CONCLUSIONS: Insulin resistance could be associated with BA advancement in girls with CPP.
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DOI
10.6065/apem.2017.22.3.176
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
강석진(Kang, Seok Jin)
권아름(Kwon, Ah Reum) ORCID logo https://orcid.org/0000-0002-9692-2135
김호성(Kim, Ho Seong) ORCID logo https://orcid.org/0000-0003-1135-099X
박소라(Park, Sora)
정모경(Jung, Mo Kyung)
채현욱(Chae, Hyun Wook) ORCID logo https://orcid.org/0000-0001-5016-8539
허진호(Hur, Jin Ho)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161030
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