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Atrial fibrillation and the risk of myocardial infarction: a nation-wide propensity-matched study

Authors
 Hye Young Lee  ;  Pil-Sung Yang  ;  Tae-Hoon Kim  ;  Jae-Sun Uhm  ;  Hui-Nam Pak  ;  Moon-Hyoung Lee  ;  Boyoung Joung 
Citation
 Scientific Reports, Vol.7(1) : 12716, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
In addition to being an established complicating factor for myocardial infarction (MI), recent studies have revealed that atrial fibrillation (AF) increased risk of MI. This study is to evaluate the risk of MI associated with AF in a nationwide population based cohort. We examine the association between AF and incident MI in 497,366 adults from the Korean National Health Insurance Service database, who were free of AF and MI at baseline. AF group (n = 3,295) was compared with propensity matched no-AF group (n = 13,159). Over 4.2 years of follow up, 137 MI events occurred. AF was associated with 3-fold increased risk of MI (HR, 3.1; 95% CI, 2.22-4.37) in both men (HR, 2.91; 95% CI 1.91-4.45) and women (HR, 3.52; 95% CI 2.01-6.17). The risk of AF-associated MI was higher in patients free of hypertension, diabetes, ischemic stroke, and dyslipidemia at baseline. The cumulative incidence of AF-associated MI was lower in patients on anticoagulant and statin therapies. Our finding suggests that AF complications beyond stoke should extend to total mortality to include MI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161011
DOI
10.1038/s41598-017-13061-4
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김태훈(Kim, Tae-Hoon) ; 박희남(Pak, Hui Nam) ; 양필성(Yang, Pil Sung) ; 엄재선(Uhm, Jae Sun) ; 이문형(Lee, Moon Hyoung) ; 정보영(Joung, Bo Young)
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