Cited 29 times in
Damage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea With Chronic Intermittent Hypoxia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조형주 | - |
dc.date.accessioned | 2018-07-20T08:13:53Z | - |
dc.date.available | 2018-07-20T08:13:53Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0161-8105 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160992 | - |
dc.description.abstract | Study Objectives: Investigating the exact pathophysiology of obstructive sleep apnea syndrome (OSAS)-induced hearing loss is critical. We sought to verify the hypothesis that a correlation exists between mitochondrial dysfunction in inner ear hair cells and the auditory dysfunction induced by chronic intermittent hypoxia (CIH) in a murine model of sleep apnea. Methods: C57BL/6J adult male mice were randomized to 4 weeks of CIH (n = 12) or normoxia (Sham) (n = 12). Hearing threshold was determined by auditory brainstem response. The activity of mitochondria was compared between CIH and Sham mice. Histological assessment and transmission electron microscopy were performed for assessing morphologic changes in mitochondria. The number of mtDNA copies as well as the levels of PGC1-α, Tfam, and VDAC (voltage-dependent anion channel) were determined in the hair cells of CIH mice. Results: We observed that hearing ability in CIH mice was impaired and hair-cell mitochondria in CIH mice were fewer compared to that in Sham and also displayed an aberrant morphology. The mRNA levels of PGC-1α and Tfam were higher in the CIH group than in the Sham group. Moreover, the expression of VDAC was increased in the tectorial membrane, the basilar membrane, and especially in the inner hair cells of CIH mice. Conclusions: This study using CIH mice as a model for OSAS provides evidence of an association between OSAS and auditory function alteration, as well as of mitochondria being part of the pathophysiology of hearing impairment. Further investigation is required to determine whether mitochondria could serve as a valid target for preventive or therapeutic purposes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Associated Professional Sleep Societies | - |
dc.relation.isPartOf | SLEEP | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal* | - |
dc.subject.MESH | Hair Cells, Auditory/pathology* | - |
dc.subject.MESH | Hypoxia/complications | - |
dc.subject.MESH | Hypoxia/pathology* | - |
dc.subject.MESH | Hypoxia/physiopathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mitochondria/pathology* | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Sleep Apnea Syndromes/etiology | - |
dc.subject.MESH | Sleep Apnea Syndromes/pathology* | - |
dc.subject.MESH | Sleep Apnea Syndromes/physiopathology* | - |
dc.subject.MESH | Sleep Apnea, Obstructive/complications | - |
dc.subject.MESH | Sleep Apnea, Obstructive/pathology | - |
dc.subject.MESH | Sleep Apnea, Obstructive/physiopathology | - |
dc.title | Damage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea With Chronic Intermittent Hypoxia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | Young Joon Seo | - |
dc.contributor.googleauthor | Hyun Mi Ju | - |
dc.contributor.googleauthor | Sun Hee Lee | - |
dc.contributor.googleauthor | Sang Hyun Kwak | - |
dc.contributor.googleauthor | Min Jung Kang | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Chang-Hoon Kim | - |
dc.contributor.googleauthor | Hyung-Ju Cho | - |
dc.identifier.doi | 10.1093/sleep/zsx106 | - |
dc.contributor.localId | A03936 | - |
dc.relation.journalcode | J02661 | - |
dc.identifier.eissn | 1550-9109 | - |
dc.identifier.pmid | 28934520 | - |
dc.identifier.url | https://academic.oup.com/sleep/article/40/9/zsx106/3896165 | - |
dc.subject.keyword | chronic intermittent hypoxia | - |
dc.subject.keyword | hearing impairment | - |
dc.subject.keyword | mitochondria | - |
dc.subject.keyword | murine model | - |
dc.subject.keyword | sleep apnea | - |
dc.contributor.alternativeName | Cho, Hyung Ju | - |
dc.contributor.affiliatedAuthor | Cho, Hyung Ju | - |
dc.citation.volume | 40 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | zsx106 | - |
dc.identifier.bibliographicCitation | SLEEP , Vol.40(9) : zsx106, 2017 | - |
dc.identifier.rimsid | 60884 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.