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Damage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea With Chronic Intermittent Hypoxia

DC Field Value Language
dc.contributor.author조형주-
dc.date.accessioned2018-07-20T08:13:53Z-
dc.date.available2018-07-20T08:13:53Z-
dc.date.issued2017-
dc.identifier.issn0161-8105-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160992-
dc.description.abstractStudy Objectives: Investigating the exact pathophysiology of obstructive sleep apnea syndrome (OSAS)-induced hearing loss is critical. We sought to verify the hypothesis that a correlation exists between mitochondrial dysfunction in inner ear hair cells and the auditory dysfunction induced by chronic intermittent hypoxia (CIH) in a murine model of sleep apnea. Methods: C57BL/6J adult male mice were randomized to 4 weeks of CIH (n = 12) or normoxia (Sham) (n = 12). Hearing threshold was determined by auditory brainstem response. The activity of mitochondria was compared between CIH and Sham mice. Histological assessment and transmission electron microscopy were performed for assessing morphologic changes in mitochondria. The number of mtDNA copies as well as the levels of PGC1-α, Tfam, and VDAC (voltage-dependent anion channel) were determined in the hair cells of CIH mice. Results: We observed that hearing ability in CIH mice was impaired and hair-cell mitochondria in CIH mice were fewer compared to that in Sham and also displayed an aberrant morphology. The mRNA levels of PGC-1α and Tfam were higher in the CIH group than in the Sham group. Moreover, the expression of VDAC was increased in the tectorial membrane, the basilar membrane, and especially in the inner hair cells of CIH mice. Conclusions: This study using CIH mice as a model for OSAS provides evidence of an association between OSAS and auditory function alteration, as well as of mitochondria being part of the pathophysiology of hearing impairment. Further investigation is required to determine whether mitochondria could serve as a valid target for preventive or therapeutic purposes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAssociated Professional Sleep Societies-
dc.relation.isPartOfSLEEP-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDisease Models, Animal*-
dc.subject.MESHHair Cells, Auditory/pathology*-
dc.subject.MESHHypoxia/complications-
dc.subject.MESHHypoxia/pathology*-
dc.subject.MESHHypoxia/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMitochondria/pathology*-
dc.subject.MESHRandom Allocation-
dc.subject.MESHSleep Apnea Syndromes/etiology-
dc.subject.MESHSleep Apnea Syndromes/pathology*-
dc.subject.MESHSleep Apnea Syndromes/physiopathology*-
dc.subject.MESHSleep Apnea, Obstructive/complications-
dc.subject.MESHSleep Apnea, Obstructive/pathology-
dc.subject.MESHSleep Apnea, Obstructive/physiopathology-
dc.titleDamage of Inner Ear Sensory Hair Cells via Mitochondrial Loss in a Murine Model of Sleep Apnea With Chronic Intermittent Hypoxia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorYoung Joon Seo-
dc.contributor.googleauthorHyun Mi Ju-
dc.contributor.googleauthorSun Hee Lee-
dc.contributor.googleauthorSang Hyun Kwak-
dc.contributor.googleauthorMin Jung Kang-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorChang-Hoon Kim-
dc.contributor.googleauthorHyung-Ju Cho-
dc.identifier.doi10.1093/sleep/zsx106-
dc.contributor.localIdA03936-
dc.relation.journalcodeJ02661-
dc.identifier.eissn1550-9109-
dc.identifier.pmid28934520-
dc.identifier.urlhttps://academic.oup.com/sleep/article/40/9/zsx106/3896165-
dc.subject.keywordchronic intermittent hypoxia-
dc.subject.keywordhearing impairment-
dc.subject.keywordmitochondria-
dc.subject.keywordmurine model-
dc.subject.keywordsleep apnea-
dc.contributor.alternativeNameCho, Hyung Ju-
dc.contributor.affiliatedAuthorCho, Hyung Ju-
dc.citation.volume40-
dc.citation.number9-
dc.citation.startPagezsx106-
dc.identifier.bibliographicCitationSLEEP , Vol.40(9) : zsx106, 2017-
dc.identifier.rimsid60884-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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