Cited 13 times in
Five factor score of more than 1 is associated with relapse during the first 2 year-follow up in patients with eosinophilic granulomatosis with polyangiitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 이상원 | - |
dc.date.accessioned | 2018-07-20T08:13:14Z | - |
dc.date.available | 2018-07-20T08:13:14Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160981 | - |
dc.description.abstract | AIM: We investigated what variables at diagnosis might be associated with the relapse of eosinophilic granulomatosis with polyangiitis (EGPA) and whether five factor score (FFS) at diagnosis might predict it. METHODS: We reviewed the medical records of 30 patients with EGPA having results of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) and proteinase 3 (PR3)-ANCA and having achieved remission during the first therapeutic regimen administration within follow-up duration for at least more than 2 years. Clinical manifestations, the presence of relapse and items for FFS at diagnosis were collected and compared among groups. RESULTS: The mean age of patients (18 women) was 50.3 years and the mean follow-up duration was 2175 days. EGPA patients having MPO-ANCA had shown higher frequency of skin involvement and proteinuria over 1 g/day than those having PR3-ANCA and no ANCA. EGPA patients with relapse had more frequent baseline MPO-ANCA and kidney involvement,including proteinuria over 1 g/day and renal insufficiency and higher FFS at diagnosis than those without. However, only FFS showed the predictive significance for relapse (Exp(B) 2.624, P = 0.014) on Cox Hazard model analysis. When the cutoff of FFS for the relapse was set as 1, relapse was identified more frequently in patients with FFS ≥ 1 than those with FFS <1 (68.8% vs. 7.1%, P = 0.001; relative risk 28.6). CONCLUSION: In this study, FFS at diagnosis was associated with relapse and FFS ≥ 1 was the independent predictor of relapse during follow-up for more than 2 years. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley on behalf of the Asia Pacific League of Associations for Rheumatology | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Five factor score of more than 1 is associated with relapse during the first 2 year-follow up in patients with eosinophilic granulomatosis with polyangiitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Dae Sik Kim | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong‐Beom Park | - |
dc.contributor.googleauthor | Sang‐Won Lee | - |
dc.identifier.doi | 10.1111/1756-185X.13056 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01158 | - |
dc.identifier.eissn | 1756-185X | - |
dc.identifier.pmid | 28261989 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13056 | - |
dc.subject.keyword | MPO-ANCA | - |
dc.subject.keyword | Relapse | - |
dc.subject.keyword | eosinophilic granulomatosis with polyangiitis | - |
dc.subject.keyword | kidney involvement | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.citation.volume | 20 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1261 | - |
dc.citation.endPage | 1268 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.20(9) : 1261-1268, 2017 | - |
dc.identifier.rimsid | 60873 | - |
dc.type.rims | ART | - |
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