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Five factor score of more than 1 is associated with relapse during the first 2 year-follow up in patients with eosinophilic granulomatosis with polyangiitis

DC FieldValueLanguage
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.date.accessioned2018-07-20T08:13:14Z-
dc.date.available2018-07-20T08:13:14Z-
dc.date.issued2017-
dc.identifier.issn1756-1841-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160981-
dc.description.abstractAIM: We investigated what variables at diagnosis might be associated with the relapse of eosinophilic granulomatosis with polyangiitis (EGPA) and whether five factor score (FFS) at diagnosis might predict it. METHODS: We reviewed the medical records of 30 patients with EGPA having results of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) and proteinase 3 (PR3)-ANCA and having achieved remission during the first therapeutic regimen administration within follow-up duration for at least more than 2 years. Clinical manifestations, the presence of relapse and items for FFS at diagnosis were collected and compared among groups. RESULTS: The mean age of patients (18 women) was 50.3 years and the mean follow-up duration was 2175 days. EGPA patients having MPO-ANCA had shown higher frequency of skin involvement and proteinuria over 1 g/day than those having PR3-ANCA and no ANCA. EGPA patients with relapse had more frequent baseline MPO-ANCA and kidney involvement,including proteinuria over 1 g/day and renal insufficiency and higher FFS at diagnosis than those without. However, only FFS showed the predictive significance for relapse (Exp(B) 2.624, P = 0.014) on Cox Hazard model analysis. When the cutoff of FFS for the relapse was set as 1, relapse was identified more frequently in patients with FFS ≥ 1 than those with FFS <1 (68.8% vs. 7.1%, P = 0.001; relative risk 28.6). CONCLUSION: In this study, FFS at diagnosis was associated with relapse and FFS ≥ 1 was the independent predictor of relapse during follow-up for more than 2 years.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley on behalf of the Asia Pacific League of Associations for Rheumatology-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFive factor score of more than 1 is associated with relapse during the first 2 year-follow up in patients with eosinophilic granulomatosis with polyangiitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDae Sik Kim-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong‐Beom Park-
dc.contributor.googleauthorSang‐Won Lee-
dc.identifier.doi10.1111/1756-185X.13056-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.relation.journalcodeJ01158-
dc.identifier.eissn1756-185X-
dc.identifier.pmid28261989-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13056-
dc.subject.keywordMPO-ANCA-
dc.subject.keywordRelapse-
dc.subject.keywordeosinophilic granulomatosis with polyangiitis-
dc.subject.keywordkidney involvement-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.citation.volume20-
dc.citation.number9-
dc.citation.startPage1261-
dc.citation.endPage1268-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.20(9) : 1261-1268, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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